Grennan D M, Howie A D, Moran F, Buchanan W W
Ann Rheum Dis. 1978 Dec;37(6):536-9. doi: 10.1136/ard.37.6.536.
Several series have suggested that pulmonary function abnormalities are common in systemic lupus erythematosus. However, only isolated studies have attempted to relate these abnormalities to immunological aspects of the diseases. In the present study respiratory symptoms, pulmonary function tests, and immunological data were reviewed in 22 patients with systemic lupus erythematosus. Seventeen subjects had either clinical evidence or abnormalities of lung function suggestive of pulmonary involvement. A restrictive ventilatory defect or reduction in pulmonary diffusing capacity for carbon monoxide was demonstrated in 14 of the patients only 4 of whom were dyspnoeic. There was no correlation between pulmonary involvement, co-existent renal lupus, and immunological abnormality.
多项研究表明，肺功能异常在系统性红斑狼疮中很常见。然而，只有个别研究试图将这些异常与疾病的免疫学方面联系起来。在本研究中，我们回顾了22例系统性红斑狼疮患者的呼吸道症状、肺功能测试和免疫学数据。17名受试者有临床证据或肺功能异常提示肺部受累。14例患者出现限制性通气功能障碍或一氧化碳肺弥散能力降低，其中只有4例有呼吸困难。肺部受累、并存的狼疮性肾炎和免疫学异常之间没有相关性。
