Department of Audiology and Speech Pathology, College of Health Professions, The University of Tennessee Health Science Center, Knoxville, TN 37996, United States.
School of Communication Sciences and Disorders, Western University, London, Ontario N6G 1H1, Canada.
Brain Lang. 2021 Jul;218:104950. doi: 10.1016/j.bandl.2021.104950. Epub 2021 Apr 6.
Individuals with primary progressive aphasia (PPA) exhibit differential impairment patterns in noun and verb naming, but it remains unclear whether anomia treatment results in similar improvements in noun and verb naming. Therefore, we examined the immediate and long-term (3-months post-treatment) behavioral and neural effects of an anomia treatment on object and action naming skills in PPA. A case-series design was utilized involving two individuals with PPA. Object and action words were trained concurrently and probed regularly using word lists matched on a number of lexical characteristics. One participant showed improvements in all word categories with different effect sizes whereas the other participant demonstrated improved naming only on trained object words. Treatment-induced fMRI changes were found in both hemispheres, with distinct patterns observed across participants. Further research is needed to better understand the effects of residual language and cognitive skills on behavioral and neurophysiological outcomes following anomia treatment for PPA.
患有原发性进行性失语症 (PPA) 的个体在名词和动词命名方面表现出不同的损伤模式，但目前尚不清楚命名障碍治疗是否会导致名词和动词命名的类似改善。因此，我们研究了命名障碍治疗对 PPA 中物体和动作命名技能的即时和长期（治疗后 3 个月）行为和神经影响。使用病例系列设计，涉及两名 PPA 患者。物体和动作词同时进行训练，并使用在多个词汇特征上匹配的单词列表定期进行探测。一名参与者在所有单词类别中都表现出不同效果大小的改善，而另一名参与者仅在训练过的物体单词上表现出命名改善。在两个半球中都发现了治疗引起的 fMRI 变化，在不同参与者中观察到不同的模式。需要进一步的研究来更好地理解残余语言和认知技能对 PPA 命名障碍治疗后行为和神经生理结果的影响。
