Parker Alison E, Scull Tracy M, Morrison Abigail M
innovation Research & Training, Durham, NC, USA.
J Child Health Care. 2022 Mar;26(1):139-153. doi: 10.1177/13674935211003774. Epub 2021 Apr 9.
Pediatric clinical trials allow for the testing of appropriate and effective treatments for children. However, some challenges exist with recruitment. This study examined the effectiveness of , an interactive, multimedia website (which includes activities, videos, and comic books) designed to educate children about clinical trials. A randomized controlled trial was conducted in 2018 with 91 participants ( = 10.92 years; = 2.06). Participants were randomly assigned to intervention or wait-list control groups and completed questionnaires at pretest and posttest (1 week later) about their knowledge, attitudes, beliefs about clinical trials, and self-efficacy for participating in clinical trials. Participants in the intervention group received access to between pretest and posttest and completed a satisfaction questionnaire at posttest. At the end of the study, participants in the wait-list control group were offered the option to use the website and complete a satisfaction questionnaire. At posttest, participants in the intervention group, compared to participants in the wait-list control group, had more knowledge about clinical trials and more reported confidence for participating in clinical trials. Participants reported high levels of satisfaction with . The findings suggest that an educational website can improve factors related to increasing rates of participation in clinical trials.
儿科临床试验有助于测试适合儿童的有效治疗方法。然而，在招募方面存在一些挑战。本研究考察了一个交互式多媒体网站（包括活动、视频和漫画书）的效果，该网站旨在对儿童进行临床试验相关教育。2018年进行了一项随机对照试验，有91名参与者（平均年龄=10.92岁；标准差=2.06）。参与者被随机分配到干预组或候补对照组，并在预测试和后测试（1周后）时完成关于他们对临床试验的知识、态度、信念以及参与临床试验的自我效能感的问卷。干预组的参与者在预测试和后测试之间可以访问该网站，并在后测试时完成一份满意度问卷。在研究结束时，候补对照组的参与者可以选择使用该网站并完成一份满意度问卷。在后测试时，与候补对照组的参与者相比，干预组的参与者对临床试验有更多的了解，并且报告称参与临床试验的信心更强。参与者对该网站的满意度很高。研究结果表明，一个教育网站可以改善与提高临床试验参与率相关的因素。
