Department of Psychology, University of Chicago, Chicago, IL, USA.
The Mind Research Network and Lovelace Biomedical, Albuquerque, NM, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
Neuroimage Clin. 2021;30:102645. doi: 10.1016/j.nicl.2021.102645. Epub 2021 Mar 27.
Much of social cognition requires making inferences about the mental and emotional states of others. Moreover, understanding the emotions of others is an important foundation for moral decision-making. Psychopathy is associated with both aberrant emotional understanding and atypical hemodynamic responses when viewing and evaluating morally laden social interactions. In the present functional MRI study, female inmates (N = 107) were asked to evaluate the likely emotional state of either the recipient or the initiator of harmful or helpful interactions. Psychopathy was assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R scores were not associated with differences in confidence or accuracy ratings. However, psychopathy scores were significantly related to increased hemodynamic response in right dorsolateral prefrontal cortex when viewing harmful interactions and decreased functional connectivity from right amygdala to inferior parietal cortex and insula, and from temporal parietal junction to dorsomedial prefrontal cortex. Overall, this work indicates that in females, psychopathy is associated with normal behavioral accuracy and confidence but alterations in neural network activity during moral decision-making.
社会认知很大程度上需要对他人的心理和情绪状态进行推断。此外，理解他人的情绪是道德决策的重要基础。精神病态与情绪理解异常以及在观看和评估道德相关社会互动时出现非典型的血液动力学反应有关。在本项功能磁共振成像研究中，要求女性囚犯（N=107）评估有害或有益互动的接受者或发起者的情绪状态。使用修订后的精神病态检查表（PCL-R）评估精神病态。PCL-R 评分与置信度或准确性评分的差异无关。但是，当观看有害互动时，精神病态评分与右侧背外侧前额叶皮质的血液动力学反应增加显著相关，而右侧杏仁核到下顶叶皮质和岛叶，以及颞顶联合区到背内侧前额叶皮质的功能连接减少。总的来说，这项工作表明，在女性中，精神病态与正常的行为准确性和信心有关，但在道德决策过程中神经网络活动发生了改变。
