Department of Dermatology and Venereology, Tanta University Faculty of Medicine, Tanta, Egypt.
Pathology Department, Tanta University Faculty of Medicine, Tanta, Egypt.
J Cosmet Laser Ther. 2020 Nov 16;22(6-8):256-264. doi: 10.1080/14764172.2021.1880598. Epub 2021 Apr 12.
Skin aging may be divided into intrinsic and extrinsic aging or photoaging. The first is a natural, slow and gradual process. The second is exacerbated by environmental factors such as improper exposure to sunlight. There are a myriad of therapeutic modalities that can improve photoaging. Intense pulsed light, radiofrequency and carboxytherapy are good procedural modalities to improve skin aging. This study aimed to evaluate and compare the efficacy and safety of IPL, RF, and carboxytherapy in facial rejuvenation. This study included 60 patients with facial wrinkles. Patients were divided into three groups. Group 1 was treated with IPL, group 2 was treated with radiofrequency while group 3 was treated with carboxytherapy. All patients received four sessions with 3-4 week interval and followed up after 3 months after the end of treatment. Patients were assessed by digital photographing and skin biopsies before and after treatment. There was a significant difference in the percentage of improvement and patients' satisfaction with more significance in group 1, followed by group 3 then group 2. IPL was the more effective, followed by carboxytherapy then RF at the end in facial rejuvenation. These results were confirmed by immunohistochemical expression of MMP1.
皮肤老化可分为内源性和外源性老化或光老化。前者是一种自然的、缓慢而渐进的过程，后者则由阳光暴露不当等环境因素加剧。有许多治疗方法可以改善光老化。强脉冲光、射频和羧基疗法是改善皮肤老化的良好程序方法。本研究旨在评估和比较 IPL、RF 和羧基疗法对面部年轻化的疗效和安全性。本研究纳入了 60 例面部皱纹患者。患者分为三组，第 1 组接受 IPL 治疗，第 2 组接受射频治疗，第 3 组接受羧基疗法。所有患者均接受 4 次治疗，间隔 3-4 周，治疗结束后 3 个月进行随访。治疗前后通过数字摄影和皮肤活检评估患者。改善百分比和患者满意度有显著差异，第 1 组更有意义，其次是第 3 组，然后是第 2 组。在面部年轻化方面， IPL 更有效，其次是羧基疗法，最后是 RF。这些结果通过 MMP1 的免疫组化表达得到证实。
