神经病学与新冠疫情：收集数据以做出明智应对
Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response.
作者信息
High Brigit, Hixon Alison M, Tyler Kenneth L, Piquet Amanda L, Pelak Victoria S
机构信息
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
出版信息
Neurol Clin Pract. 2021 Apr;11(2):e48-e63. doi: 10.1212/CPJ.0000000000000908.
PURPOSE OF REVIEW
The current coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the greatest medical crises faced by our current generation of health care providers. Although much remains to be learned about the pathophysiology of SARS-CoV-2, there is both historical precedent from other coronaviruses and a growing number of case reports and series that point to neurologic consequences of COVID-19.
RECENT FINDINGS
Olfactory/taste disturbances and increased risk of strokes and encephalopathies have emerged as potential consequences of COVID-19 infection. Evidence regarding whether these sequelae result indirectly from systemic infection or directly from neuroinvasion by SARS-CoV-2 is emerging.
SUMMARY
This review summarizes the current understanding of SARS-CoV-2 placed in context with our knowledge of other human coronaviruses. Evidence and data regarding neurologic sequelae of COVID-19 and the neuroinvasive potential of human coronaviruses are provided along with a summary of patient registries of interest to the Neurology community.
综述目的
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行是我们这一代医疗保健提供者面临的最重大医疗危机之一。尽管关于SARS-CoV-2的病理生理学仍有许多有待了解之处，但其他冠状病毒有历史先例，且越来越多的病例报告和系列研究指出了COVID-19的神经学后果。
最新发现
嗅觉/味觉障碍以及中风和脑病风险增加已成为COVID-19感染的潜在后果。关于这些后遗症是由全身感染间接导致还是由SARS-CoV-2神经侵袭直接导致的证据正在出现。
总结
本综述结合我们对其他人类冠状病毒的了解，总结了目前对SARS-CoV-2的认识。提供了关于COVID-19神经后遗症以及人类冠状病毒神经侵袭潜力的证据和数据，同时总结了神经学界感兴趣的患者登记情况。
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