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Human-specific polymorphic pseudogenization of protects against advanced cancer progression.人类特异性的多态性假基因化可预防晚期癌症进展。
FASEB Bioadv. 2020 Dec 8;3(2):69-82. doi: 10.1096/fba.2020-00092. eCollection 2021 Feb.
2
Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.超高敏 TP53 测序用于癌症检测,揭示了在人类一个多世纪的寿命中,正常组织中克隆选择的渐进性。
Cell Rep. 2019 Jul 2;28(1):132-144.e3. doi: 10.1016/j.celrep.2019.05.109.
3
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues.RNA 序列分析揭示了正常组织中的宏观体细胞克隆扩张。
Science. 2019 Jun 7;364(6444). doi: 10.1126/science.aaw0726.
4
Genes that improved fitness also cost modern humans: evidence for genes with antagonistic effects on longevity and disease.提高适应性的基因也让现代人类付出了代价:对寿命和疾病具有拮抗作用的基因的证据。
Evol Med Public Health. 2019 Jan 23;2019(1):4-6. doi: 10.1093/emph/eoz002. eCollection 2019.
5
Is antagonistic pleiotropy ubiquitous in aging biology?拮抗性多效性在衰老生物学中普遍存在吗?
Evol Med Public Health. 2018 Oct 11;2018(1):287-294. doi: 10.1093/emph/eoy033. eCollection 2018.
6
Selective Pressures on Human Cancer Genes along the Evolution of Mammals.哺乳动物进化过程中人类癌症基因所面临的选择压力。
Genes (Basel). 2018 Nov 28;9(12):582. doi: 10.3390/genes9120582.
7
Somatic mutant clones colonize the human esophagus with age.随着年龄的增长,体细胞突变克隆会在人体食管中定植。
Science. 2018 Nov 23;362(6417):911-917. doi: 10.1126/science.aau3879. Epub 2018 Oct 18.
8
Population dynamics of normal human blood inferred from somatic mutations.从体细胞突变推断正常人体血液的种群动态。
Nature. 2018 Sep;561(7724):473-478. doi: 10.1038/s41586-018-0497-0. Epub 2018 Sep 5.
9
Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation.247 项全基因组关联研究的联合分析揭示了癌症高风险是进化适应的结果。
Mol Biol Evol. 2018 Feb 1;35(2):473-485. doi: 10.1093/molbev/msx305.
10
Antagonistic pleiotropy and mutation accumulation influence human senescence and disease.拮抗性多效性和突变积累影响人类衰老和疾病。
Nat Ecol Evol. 2017 Jan 30;1(3):55. doi: 10.1038/s41559-016-0055.

Broadening the spectrum of cancer genes under selection in human populations.

作者信息

Voskarides Konstantinos

机构信息

Medical School University of Cyprus Nicosia Cyprus.

出版信息

FASEB Bioadv. 2021 Mar 27;3(4):275-277. doi: 10.1096/fba.2020-00150. eCollection 2021 Apr.

DOI:10.1096/fba.2020-00150
PMID:33842852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8019256/
Abstract
摘要