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Broadening the spectrum of cancer genes under selection in human populations.拓宽人类群体中正在接受选择的癌症基因谱。
FASEB Bioadv. 2021 Mar 27;3(4):275-277. doi: 10.1096/fba.2020-00150. eCollection 2021 Apr.
2
Human-specific polymorphic pseudogenization of protects against advanced cancer progression.人类特异性的多态性假基因化可预防晚期癌症进展。
FASEB Bioadv. 2020 Dec 8;3(2):69-82. doi: 10.1096/fba.2020-00092. eCollection 2021 Feb.
3
Antagonistic Pleiotropy in Human Disease.人类疾病中的拮抗多效性
J Mol Evol. 2020 Jan;88(1):12-25. doi: 10.1007/s00239-019-09923-2. Epub 2019 Dec 21.
4
Genes that improved fitness also cost modern humans: evidence for genes with antagonistic effects on longevity and disease.提高适应性的基因也让现代人类付出了代价：对寿命和疾病具有拮抗作用的基因的证据。
Evol Med Public Health. 2019 Jan 23;2019(1):4-6. doi: 10.1093/emph/eoz002. eCollection 2019.
5
Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.Siglec 基因赋予人类和小鼠对系统性红斑狼疮的抗性。
Cell Mol Immunol. 2019 Feb;16(2):154-164. doi: 10.1038/cmi.2017.160. Epub 2018 Mar 5.
6
Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation.247 项全基因组关联研究的联合分析揭示了癌症高风险是进化适应的结果。
Mol Biol Evol. 2018 Feb 1;35(2):473-485. doi: 10.1093/molbev/msx305.
7
The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.具有阿尔茨海默病保护作用的CD33剪接变体通过转移至细胞内池介导适应性功能丧失。
J Biol Chem. 2017 Sep 15;292(37):15312-15320. doi: 10.1074/jbc.M117.799346. Epub 2017 Jul 26.
8
Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.CD33及其他基因的人类特异性衍生等位基因可预防生殖后期认知能力下降。
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):74-9. doi: 10.1073/pnas.1517951112. Epub 2015 Nov 30.
9
On the apparent rarity of epithelial cancers in captive chimpanzees.关于圈养黑猩猩上皮癌明显罕见的情况。
Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). doi: 10.1098/rstb.2014.0225.
10
Grandmothers and the evolution of human longevity: a review of findings and future directions.祖母与人类长寿的进化：研究发现与未来方向综述。
Evol Anthropol. 2013 Nov-Dec;22(6):294-302. doi: 10.1002/evan.21382.

Ongoing selection for a uniquely human null allele of in world-wide populations may protect against the risk of advanced carcinomas.

作者信息

Siddiqui Shoib S, Vaill Michael, Varki Ajit

机构信息

Departments of Medicine and Cellular and Molecular Medicine Glycobiology Research and Training Center, and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.

Present address: School of Life and Medical Sciences University of Hertfordshire Hatfield UK.

出版信息

FASEB Bioadv. 2021 Mar 30;3(4):278-279. doi: 10.1096/fba.2021-00036. eCollection 2021 Apr.

DOI:10.1096/fba.2021-00036
PMID:33842853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8019254/
Abstract
摘要