Ravazzola M, Baetens D, Engerman R, Kovacevic N, Vranic M, Orci L
Horm Metab Res. 1977 Nov;9(6):480-3. doi: 10.1055/s-0028-1093504.
Immunofluorescence shows that the oxyntic mucosa of a dog depancreatized for 5 years and having a poorly-controlled diabetes has more glucagon- and somatostatin-containing cells than the mucosa of a control dog. At the ultrastructural level, 4 endocrine cell types are identified: A-, A-like, D- and enterochromaffin-like (ECL) cells, with increased numbers of A-, A-like and D-cells in gastric glands of the depancreatized dog, together with a higher concentration of immunoreactive glucagon in the gastric mucosa. The increase in A-, A-like and D-cells is compatible with: a) a change induced by the diabetic state itself; b) a hyperplasia secondary to the loss of corresponding pancreatic cells. At any rate, the fact that A-, A-like and D-cells increase parallely may indicate that these three cell types are functionally related one with another.
免疫荧光显示，一只胰腺切除5年且糖尿病控制不佳的狗的胃黏膜中，含胰高血糖素和生长抑素的细胞比对照狗的黏膜更多。在超微结构水平上，鉴定出4种内分泌细胞类型：A细胞、A样细胞、D细胞和肠嗜铬样（ECL）细胞，胰腺切除狗的胃腺中A细胞、A样细胞和D细胞数量增加，同时胃黏膜中免疫反应性胰高血糖素浓度更高。A细胞、A样细胞和D细胞数量的增加符合以下情况：a）糖尿病状态本身引起的变化；b）相应胰腺细胞丧失后的增生。无论如何，A细胞、A样细胞和D细胞平行增加这一事实可能表明这三种细胞类型在功能上相互关联。
