Kim Soo-Yeon, Kim Ah Rim
Department of Nursing, Daegu Haany University, Hanuidae-ro, Gyeongsan-si, Gyeongsangbuk-do, 38609, Republic of Korea.
Department of Nursing, Far East University, Chungchungbuk-do, South Korea.
Syst Rev. 2021 Apr 13;10(1):106. doi: 10.1186/s13643-021-01662-0.
Schizophrenia requires a community-based intervention approach combined with standard treatment to prevent relapses. A literature review is required to understand the effectiveness of community-based interventions and to enhance quality in countries where they have not been fully established. This is a protocol for a systematic review of the effectiveness of community-based interventions for patients with schizophrenia spectrum disorders.
We will search (from inception to January 2021) PubMed/MEDLINE, EMBASE, PsycINFO, CENTRAL, CINAHL, and Research Information Sharing Service/Korean databases. Randomized controlled trials on community-based interventions for patients with schizophrenia spectrum disorders will be eligible. The comparison groups will include patients with schizophrenia spectrum disorders who are only receiving the usual care and those who also receive community-based interventions. The schizophrenia spectrum disorders referred to in this study are defined according to the DSM-5: delusional disorders, schizophrenic disorders, and schizoaffective disorder will be included. Relapse/re-hospitalization rates (primary outcome) and quality of life (secondary outcome) will be identified for each group. Two reviewers will independently screen study titles, abstract data, and full-text articles and perform the data extraction process. Potential conflicts will be resolved through discussion. The study risk of bias will be appraised using the Cochrane Risk of Bias 2.0 tool. Results will be descriptively synthesized and will be structured according to patients' characteristics, intervention type and exposure, and outcome type. If feasible and appropriate, outcome data will be used to perform random effects meta-analyses. Discrete variables will be calculated via odds ratio, and continuous variables will be calculated via standardized mean difference using RevMan 5.3 software.
We will provide a summary of the available evidence on the effectiveness of community-based interventions and specific guidelines to improve their outcomes.
PROSPERO ( CRD42019145660 ).
精神分裂症需要采用基于社区的干预方法并结合标准治疗来预防复发。需要进行文献综述，以了解基于社区的干预措施的有效性，并在尚未充分建立这些措施的国家提高其质量。这是一项关于对精神分裂症谱系障碍患者基于社区的干预措施有效性的系统评价方案。
我们将检索（从数据库建立至2021年1月）PubMed/MEDLINE、EMBASE、PsycINFO、CENTRAL、CINAHL以及研究信息共享服务/韩国数据库。关于对精神分裂症谱系障碍患者基于社区的干预措施的随机对照试验将符合纳入标准。对照组将包括仅接受常规护理的精神分裂症谱系障碍患者以及同时接受基于社区的干预措施的患者。本研究中提及的精神分裂症谱系障碍根据《精神疾病诊断与统计手册》第5版进行定义：将包括妄想障碍、精神分裂症以及分裂情感性障碍。将确定每组的复发/再住院率（主要结局）和生活质量（次要结局）。两名评价者将独立筛选研究标题、摘要数据和全文文章，并进行数据提取过程。潜在冲突将通过讨论解决。将使用Cochrane偏倚风险2.0工具评估研究的偏倚风险。结果将进行描述性综合，并根据患者特征、干预类型和暴露情况以及结局类型进行组织。如果可行且合适，将使用结局数据进行随机效应荟萃分析。离散变量将通过比值比计算，连续变量将使用RevMan 5.3软件通过标准化均数差计算。
我们将提供关于基于社区的干预措施有效性的现有证据总结以及改善其结局的具体指南。
PROSPERO（CRD42019145660）
