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气管支气管骨软骨化生:慢性咳嗽和咯血的一个病因。

Tracheobronchopathia osteochondroplastica: a cause of chronic cough and haemoptysis.

作者信息

Shahzad Talha, Rizvi Nadeem, Siddiqui Sabeeh, Ahmed Rashida

机构信息

Pulmonary Medicine, The Aga Khan University Hospital, Karachi, Pakistan

Pulmonary Medicine, Ziauddin University Hospital, Karachi, Pakistan.

出版信息

BMJ Case Rep. 2021 Apr 12;14(4):e240125. doi: 10.1136/bcr-2020-240125.

Abstract

Tracheobronchopathia osteochondroplastica (TPO) is a rare disorder of the tracheopulmonary tree characterised by osseous and cartilaginous submucosal nodules projecting into the tracheal lumen, sparing the posterior tracheal membranous wall. Symptoms are non-specific and may include dry cough, hoarseness, dyspnoea, recurrent pneumonia and occasionally haemoptysis. A fibreoptic bronchoscopy showing multiple tracheal nodules followed by pathological biopsy is required to reach the final diagnosis. Here, we report two cases of TPO, both with history of biomass fuel exposure and almost similar clinical presentions with chronic cough, shortness of breath and intermittent haemoptysis. They both underwent fibreoptic bronchoscopy showing multiple tracheal nodules whose histopathological analysis showed the diagnosis of TPO. Both patients were treated conservatively and remained in good health afterwards. Physicians should be aware about the need of advanced surgical procedures including endotracheal stent placement in more severe cases.

摘要

骨软骨瘤样气管支气管病(TPO)是一种气管肺树的罕见疾病,其特征是骨和软骨性黏膜下结节突入气管腔,气管后壁膜性壁不受累。症状不具特异性,可能包括干咳、声音嘶哑、呼吸困难、反复肺炎,偶尔咯血。最终诊断需要纤维支气管镜检查显示多个气管结节,随后进行病理活检。在此,我们报告两例TPO病例,均有生物质燃料暴露史,临床表现几乎相似,均有慢性咳嗽、呼吸急促和间歇性咯血。他们都接受了纤维支气管镜检查,显示多个气管结节,其组织病理学分析确诊为TPO。两名患者均接受了保守治疗,之后健康状况良好。医生应意识到在更严重的病例中需要先进的手术程序,包括气管内支架置入。

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Tracheobronchopathia osteochondroplastica following laryngeal tuberculosis.喉结核后气管支气管骨软骨化生
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