Jung Hwa Sik, Chae Ganghee, Kim Jin Hyoung, Park Chui Yong, Lim Soyeoun, Park Soon Eun, Kim Ho Chang, Lee Young Jae, Kang Sung Kwon, Kim Don Han, Lee Yongjik, Lee Taehoon
Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 44033, Korea.
Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Sci Rep. 2021 Apr 12;11(1):7958. doi: 10.1038/s41598-021-87142-w.
Central airway obstruction (CAO) can be attributed to several benign or malignant conditions. Although surgery is the preferred therapeutic option for the management of CAO, bronchoscopic treatment can be performed in scenarios where the surgical procedure is not possible. Recent years have witnessed several improvements in the field of bronchoscopic treatment, especially with regard to airway stents. Current research involves new attempts to overcome the existing shortcomings pertaining to the stents (migration, mucostasis, and granulation tissue formation). The authors have recently developed a new silicone airway stent (GINA stent) with an anti-migration design, dynamic structure that enables the reduction of stent cross-sectional area, and radio-opacity. The present study aimed to evaluate the mechanical characteristics and performance of the novel GINA stent using a porcine tracheal stenosis model. In the current study, all the tests involved the comparison of the GINA stent [outer diameter (OD, mm): 14; length (L, mm): 55] with the Dumon stent (OD: 14; L: 50). The mechanical tests were performed using a digital force gauge, in order to determine the anti-migration force, expansion force, and flexibility. The present study evaluated the short-term (3 weeks) performance of the two stents after implantation [GINA (n = 4) vs. Dumon (n = 3)] in the porcine tracheal stenosis model. The results pertaining to the comparison of the mechanical properties of the GINA and Dumon stents are stated as follows: anti-migration force (18.4 vs. 12.8 N, P = 0.008); expansion force (11.9 vs. 14.5 N, P = 0.008); and flexibility (3.1 vs. 4.5 N, P = 0.008). The results pertaining to the comparison of the short-term performance of the GINA and Dumon stents are stated as follows: mucus retention (0/4 vs. 0/3); granulation tissue formation (0/4 vs. 0/3); and migration (1/4 vs. 2/3). The GINA stent displayed better mechanical properties and comparable short-term performance, compared to the Dumon stent.
中央气道阻塞（CAO）可归因于多种良性或恶性疾病。虽然手术是治疗CAO的首选方法，但在无法进行手术的情况下可采用支气管镜治疗。近年来，支气管镜治疗领域有了一些进展，特别是在气道支架方面。目前的研究涉及克服现有支架缺点（移位、黏液潴留和肉芽组织形成）的新尝试。作者最近开发了一种新型硅胶气道支架（GINA支架），具有抗移位设计、能减小支架横截面积的动态结构以及射线不透性。本研究旨在使用猪气管狭窄模型评估新型GINA支架的力学特性和性能。在本研究中，所有测试都将GINA支架[外径（OD，mm）：14；长度（L，mm）：55]与杜蒙支架（OD：14；L：50）进行比较。使用数字测力计进行力学测试，以确定抗移位力、扩张力和柔韧性。本研究评估了在猪气管狭窄模型中植入两种支架[GINA（n = 4）与杜蒙（n = 3）]后的短期（3周）性能。GINA支架和杜蒙支架力学性能比较的结果如下：抗移位力（18.4对12.8 N，P = 0.008）；扩张力（11.9对14.5 N，P = 0.008）；柔韧性（3.1对4.5 N，P = 0.008）。GINA支架和杜蒙支架短期性能比较的结果如下：黏液潴留（0/4对0/3）；肉芽组织形成（0/4对0/3）；移位（1/4对2/3）。与杜蒙支架相比，GINA支架显示出更好的力学性能和相当的短期性能。
