Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India.
Department of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India.
J Pharm Pharmacol. 2022 Feb 1;74(2):147-161. doi: 10.1093/jpp/rgab047.
Scopoletin (6-methoxy-7-hydroxycoumarin) is a naturally occurring coumarin belonging to the category of secondary metabolites. Coumarins are commonly found in several herbs and play a prominent role in the defense mechanism of plants. Beneficial effects of scopoletin including antioxidant, anti-diabetic, hepatoprotective, neuroprotective and anti-microbial activity induced via numerous intracellular signalling mechanisms have been widely studied. However, anti-inflammation and anti-tumorigenesis properties of scopoletin are not well documented in the literature. Therefore, the primary focus of the present review was to highlight the plethora of research pertaining to the signalling mechanisms associated with the prevention of the progression of disease condition by scopoletin.
Multiple signalling pathways like nuclear erythroid factor-2 (NEF2)-related factor-2 (NRF-2), apoptosis/p53 signalling, nuclear factor-κB (NF-κB) signalling, autophagy signalling, hypoxia signalling, signal transducer and activator of transcription-3 (STAT3) signalling, Wnt-β signalling, Notch signalling are coupled with the anti-inflammation and anti-tumorigenesis potential of scopoletin.
Understanding crucial targets in these molecular signalling pathways may support the role of scopoletin as a promising naturally derived bioactive compound for the treatment of several diseases.
茴芹香豆素（6-甲氧基-7-羟基香豆素）是一种天然存在的香豆素，属于次生代谢产物类别。香豆素广泛存在于多种草药中，在植物的防御机制中起着重要作用。茴芹香豆素具有抗氧化、抗糖尿病、肝保护、神经保护和抗微生物活性等有益作用，其诱导作用涉及多种细胞内信号机制，已得到广泛研究。然而，茴芹香豆素的抗炎和抗肿瘤特性在文献中记载甚少。因此，本综述的主要重点是强调与通过茴芹香豆素预防疾病进展相关的信号机制的大量研究。
多种信号通路，如核红细胞因子-2（NEF2）相关因子-2（NRF-2）、细胞凋亡/p53 信号通路、核因子-κB（NF-κB）信号通路、自噬信号通路、缺氧信号通路、信号转导和转录激活因子 3（STAT3）信号通路、Wnt-β 信号通路、Notch 信号通路，与茴芹香豆素的抗炎和抗肿瘤潜力相关。
了解这些分子信号通路中的关键靶点，可能有助于支持茴芹香豆素作为一种有前途的天然生物活性化合物，用于治疗多种疾病。
