Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, India.
Phytother Res. 2021 Sep;35(9):4660-4702. doi: 10.1002/ptr.7099. Epub 2021 Apr 13.
Natural products are used since ancient times in folklore for the treatment of various ailments. Plant-derived products have been recognized for many years as a source of therapeutic agents and structural diversity. A literature survey has been carried out to determine the utility of natural molecules and their modified analogs or derivatives as pharmacological active entities. This review presents a study on the importance of natural products in terms of drug discovery and development. It describes how the natural components can be utilized after small modifications in new perspectives. Various new modifications in structure offer a unique opportunity to establish a new molecular entity with better pharmacological potential. It was concluded that in this current era, new attempts are taken to utilize the compounds derived from natural sources as novel drug candidates, with a focus to find and discover new effective molecules that were referred to as "new entities of natural product drug discovery."
天然产物自古以来就在民间医学中被用于治疗各种疾病。植物衍生产品多年来一直被认为是治疗药物和结构多样性的来源。进行了文献调查，以确定天然分子及其修饰的类似物或衍生物作为药理活性实体的用途。本综述介绍了天然产物在药物发现和开发方面的重要性研究。它描述了如何在新视角下通过微小的修饰来利用天然成分。结构的各种新修饰提供了一个独特的机会，用更好的药理潜力建立一个新的分子实体。结论是，在当前这个时代，人们正在尝试利用天然来源的化合物作为新型药物候选物，重点是寻找和发现新的有效分子，这些分子被称为“天然产物药物发现的新实体”。
