Cutler J E
Infect Immun. 1977 Dec;18(3):568-73. doi: 10.1128/iai.18.3.568-573.1977.
Candida albicans was found to produce a substance that was chemotactically active for guinea pig polymorphonuclear neutrophils. The chemotactic factor was detected in culture filtrates of organisms grown under aeration and incubated at 37 degrees C for at least 12 h. Nutrients found to be essential for the production of chemotactic factor included glucose, yeast extract, and a mixture of amino acids. Several strains of C. albicans isolated from humans were tested, and varying degrees of chemotactic activity were found to be associated with the culture filtrates. Only one of the eight isolates did not produce a measurable amount of chemotactic activity. Culture filtrates remained chemotactically active after several cycles of freezing and thawing and after heating at 90 degrees C for 10 min. Substantial evidence is presented that the chemotactic activity is not dependent upon activation of complement.
白色念珠菌被发现能产生一种对豚鼠多形核中性粒细胞具有趋化活性的物质。在通气培养并于37℃孵育至少12小时的生物体培养滤液中检测到了趋化因子。发现对趋化因子产生至关重要的营养物质包括葡萄糖、酵母提取物和氨基酸混合物。对从人类分离出的几株白色念珠菌进行了测试，发现不同程度的趋化活性与培养滤液有关。八株分离株中只有一株没有产生可测量的趋化活性。培养滤液在经过几次冻融循环以及在90℃加热10分钟后仍保持趋化活性。有大量证据表明趋化活性不依赖于补体的激活。
