益生菌因其抗炎特性对治疗婴儿腹绞痛的疗效：一项荟萃分析和系统评价
Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review.
作者信息
Shirazinia Reza, Golabchifar Ali Akbar, Fazeli Mohammad Reza
机构信息
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Pharmaceutical Quality Assurance Research Center, The institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Clin Exp Pediatr. 2021 Dec;64(12):642-651. doi: 10.3345/cep.2020.01676. Epub 2021 Apr 12.
BACKGROUND
Infantile colic (IC) is excessive crying in otherwise healthy children. Despite vast research efforts, its etiology remains unknown.
PURPOSE
Most treatments for IC carry various side effects. The collection of evidence may inform researchers of new strategies for the management and treatment of IC as well as new clues for understanding its pathogenesis. This review and meta-analysis aimed to evaluate the efficacy and possible mechanisms of probiotics for mananaging IC.
METHODS
Ten papers met the study inclusion and exclusion criteria, and the meta-analysis was conducted using Review Manager (RevMan) software and a random-effects model.
RESULTS
This meta-analysis revealed that probiotics are effective for treating infantile colic, while the review showed that this efficacy may be due to their anti-inflammatory effects.
CONCLUSION
Probiotics may be an important treatment option for managing infantile colic due to their anti-inflammatory properties.
背景
婴儿腹绞痛（IC）是指健康婴儿出现的过度哭闹。尽管进行了大量研究，但病因仍不明。
目的
大多数IC治疗方法都有各种副作用。证据收集可为研究人员提供IC管理和治疗的新策略以及理解其发病机制的新线索。本综述和荟萃分析旨在评估益生菌治疗IC的疗效及可能机制。
方法
10篇论文符合研究纳入和排除标准，使用Review Manager（RevMan）软件和随机效应模型进行荟萃分析。
结果
该荟萃分析表明益生菌对治疗婴儿腹绞痛有效，而综述显示这种疗效可能归因于其抗炎作用。
结论
由于益生菌具有抗炎特性，可能是管理婴儿腹绞痛的重要治疗选择。
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