• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

益生菌因其抗炎特性对治疗婴儿腹绞痛的疗效：一项荟萃分析和系统评价

Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review.

作者信息

Shirazinia Reza, Golabchifar Ali Akbar, Fazeli Mohammad Reza

机构信息

Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Pharmaceutical Quality Assurance Research Center, The institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Clin Exp Pediatr. 2021 Dec;64(12):642-651. doi: 10.3345/cep.2020.01676. Epub 2021 Apr 12.

DOI:10.3345/cep.2020.01676
PMID:33848417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8650819/
Abstract

BACKGROUND

Infantile colic (IC) is excessive crying in otherwise healthy children. Despite vast research efforts, its etiology remains unknown.

PURPOSE

Most treatments for IC carry various side effects. The collection of evidence may inform researchers of new strategies for the management and treatment of IC as well as new clues for understanding its pathogenesis. This review and meta-analysis aimed to evaluate the efficacy and possible mechanisms of probiotics for mananaging IC.

METHODS

Ten papers met the study inclusion and exclusion criteria, and the meta-analysis was conducted using Review Manager (RevMan) software and a random-effects model.

RESULTS

This meta-analysis revealed that probiotics are effective for treating infantile colic, while the review showed that this efficacy may be due to their anti-inflammatory effects.

CONCLUSION

Probiotics may be an important treatment option for managing infantile colic due to their anti-inflammatory properties.

摘要

背景

婴儿腹绞痛（IC）是指健康婴儿出现的过度哭闹。尽管进行了大量研究，但病因仍不明。

目的

大多数IC治疗方法都有各种副作用。证据收集可为研究人员提供IC管理和治疗的新策略以及理解其发病机制的新线索。本综述和荟萃分析旨在评估益生菌治疗IC的疗效及可能机制。

方法

10篇论文符合研究纳入和排除标准，使用Review Manager（RevMan）软件和随机效应模型进行荟萃分析。

结果

该荟萃分析表明益生菌对治疗婴儿腹绞痛有效，而综述显示这种疗效可能归因于其抗炎作用。

结论

由于益生菌具有抗炎特性，可能是管理婴儿腹绞痛的重要治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/04f5a81f18c1/cep-2020-01676f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/d5f4cd99b49c/cep-2020-01676f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/166ef30a2a31/cep-2020-01676f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/193ae63ed901/cep-2020-01676f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/04f5a81f18c1/cep-2020-01676f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/d5f4cd99b49c/cep-2020-01676f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/166ef30a2a31/cep-2020-01676f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/193ae63ed901/cep-2020-01676f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/8650819/04f5a81f18c1/cep-2020-01676f4.jpg

相似文献

1
Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review.益生菌因其抗炎特性对治疗婴儿腹绞痛的疗效：一项荟萃分析和系统评价
Clin Exp Pediatr. 2021 Dec;64(12):642-651. doi: 10.3345/cep.2020.01676. Epub 2021 Apr 12.
2
Probiotics to prevent infantile colic.预防婴儿腹绞痛的益生菌。
Cochrane Database Syst Rev. 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2.
3
A systematic review of prevention and treatment of infantile colic.婴儿腹绞痛防治的系统评价
Acta Paediatr. 2020 Sep;109(9):1733-1744. doi: 10.1111/apa.15247. Epub 2020 Jun 2.
4
Probiotics for infantile colic: a systematic review.益生菌治疗婴儿肠绞痛：系统评价。
BMC Pediatr. 2013 Nov 15;13:186. doi: 10.1186/1471-2431-13-186.
5
Parent training programmes for managing infantile colic.管理婴儿腹绞痛的家长培训项目。
Cochrane Database Syst Rev. 2019 Dec 3;12(12):CD012459. doi: 10.1002/14651858.CD012459.pub2.
6
The effectiveness of GG in the treatment of infantile colic: a systematic review and meta-analysis.西甲硅油治疗婴儿腹绞痛的有效性：一项系统评价和荟萃分析。
Transl Pediatr. 2024 Aug 31;13(8):1415-1424. doi: 10.21037/tp-24-112. Epub 2024 Aug 28.
7
The Therapeutic Benefits of Single and Multi-Strain Probiotics on Mean Daily Crying Time and Key Inflammatory Markers in Infantile Colic.单一菌株和多菌株益生菌对婴儿腹绞痛平均每日哭闹时间及关键炎症标志物的治疗益处
Cureus. 2022 Aug 24;14(8):e28363. doi: 10.7759/cureus.28363. eCollection 2022 Aug.
8
Effectiveness of probiotics in infantile colic: A rapid review.益生菌对婴儿腹绞痛的有效性：快速综述。
Paediatr Child Health. 2020 Apr;25(3):149-159. doi: 10.1093/pch/pxz007. Epub 2019 Apr 3.
9
Probiotics for the Treatment of Infantile Colic: A Systematic Review.益生菌治疗婴儿腹绞痛：一项系统评价
J Pharm Pract. 2017 Jun;30(3):366-374. doi: 10.1177/0897190016634516. Epub 2016 Mar 2.
10
Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis.益生菌预防或治疗婴儿过度哭闹的效果：系统评价和荟萃分析。
JAMA Pediatr. 2013 Dec;167(12):1150-7. doi: 10.1001/jamapediatrics.2013.2572.

引用本文的文献

1
Efficacy of Limosilactobacillus reuteri UBLRu-87 in Infantile Colic and Its Symptoms: A Double-Blind, Placebo-Controlled Study.罗伊氏乳杆菌UBLRu - 87对婴儿腹绞痛及其症状的疗效：一项双盲、安慰剂对照研究。
Cureus. 2025 Apr 7;17(4):e81856. doi: 10.7759/cureus.81856. eCollection 2025 Apr.
2
Impact of Probiotics on the Prevention and Treatment of Gastrointestinal Diseases in the Pediatric Population.益生菌对儿科人群胃肠道疾病的预防和治疗的影响。
Int J Mol Sci. 2023 May 29;24(11):9427. doi: 10.3390/ijms24119427.
3
Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome-Gut-Brain Axis in the Pathophysiology and Case Management.

本文引用的文献

1
The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.益生菌对婴儿腹绞痛症状、肠道微生物群和炎症标志物的影响：一项随机对照试验的系统评价、荟萃分析和荟萃回归
J Clin Med. 2020 Apr 2;9(4):999. doi: 10.3390/jcm9040999.
2
Recent Advancements in the Development of Modern Probiotics for Restoring Human Gut Microbiome Dysbiosis.用于恢复人类肠道微生物群失调的现代益生菌开发的最新进展
Indian J Microbiol. 2020 Mar;60(1):12-25. doi: 10.1007/s12088-019-00808-y. Epub 2019 May 25.
3
PROBIOTIC APPROACHES FOR TARGETING INFLAMMATORY BOWEL DISEASE: AN UPDATE ON ADVANCES AND OPPORTUNITIES IN MANAGING THE DISEASE.
伴有精神症状的功能性胃肠疾病：微生物群-肠-脑轴在病理生理学及病例管理中的作用
Microorganisms. 2022 Nov 7;10(11):2199. doi: 10.3390/microorganisms10112199.
4
Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome.婴儿腹绞痛与肠易激综合征的后续发展
J Neurogastroenterol Motil. 2022 Oct 30;28(4):618-629. doi: 10.5056/jnm21181.
5
Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin.通过即时检测粪便钙卫蛋白辅助诊断婴儿腹绞痛。
Front Pediatr. 2022 Sep 29;10:978545. doi: 10.3389/fped.2022.978545. eCollection 2022.
6
Nutritional Aspects of Pediatric Gastrointestinal Diseases.儿科胃肠病学的营养问题。
Nutrients. 2021 Jun 19;13(6):2109. doi: 10.3390/nu13062109.
靶向炎症性肠病的益生菌疗法：疾病管理进展与机遇的最新情况
Int J Probiotics Prebiotics. 2016;11(3-4):99-116.
4
DSM 17938 Probiotics May Increase CC-Chemokine Receptor 7 Expression in Infants Treated With for Colic.DSM 17938益生菌可能会增加因腹绞痛接受治疗的婴儿体内CC趋化因子受体7的表达。
Front Pediatr. 2019 Jul 16;7:292. doi: 10.3389/fped.2019.00292. eCollection 2019.
5
Parkinson's Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation.帕金森病：肠道微生物群失调、抗生素、益生菌及粪便微生物群移植的新作用
J Neurogastroenterol Motil. 2019 Jul 1;25(3):363-376. doi: 10.5056/jnm19044.
6
DDS-1 Modulates Intestinal-Specific Microbiota, Short-Chain Fatty Acid and Immunological Profiles in Aging Mice.DDS-1 调节衰老小鼠肠道特异性微生物群、短链脂肪酸和免疫特征。
Nutrients. 2019 Jun 7;11(6):1297. doi: 10.3390/nu11061297.
7
Probiotic : Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers.益生菌：通过改变肠道微生物群和减轻粪便炎症标志物有效治疗儿童腹泻。
Nutrients. 2019 May 23;11(5):1150. doi: 10.3390/nu11051150.
8
Role of Lactobacillus rhamnosus (FloraActive™) 19070-2 and Lactobacillus reuteri (FloraActive™) 12246 in Infant Colic: A Randomized Dietary Study.罗伊氏乳杆菌（FloraActive™）19070-2 和鼠李糖乳杆菌（FloraActive™）12246 在婴儿绞痛中的作用：一项随机饮食研究。
Nutrients. 2018 Dec 13;10(12):1975. doi: 10.3390/nu10121975.
9
Probiotics in Autoimmune and Inflammatory Disorders.益生菌与自身免疫及炎症性疾病
Nutrients. 2018 Oct 18;10(10):1537. doi: 10.3390/nu10101537.
10
Infant Colic Represents Gut Inflammation and Dysbiosis.婴儿肠绞痛代表肠道炎症和菌群失调。
J Pediatr. 2018 Dec;203:55-61.e3. doi: 10.1016/j.jpeds.2018.07.042. Epub 2018 Aug 31.