在A、C和G组链球菌疫苗超免疫的兔子中检测到自身抗体。
Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.
作者信息
Onică D, Mihalcu F, Lenkei R, Gherman M, Tudor M
出版信息
Infect Immun. 1977 Dec;18(3):624-8. doi: 10.1128/iai.18.3.624-628.1977.
Abstract
Rabbits hyperimmunized with group A, C, and G streptococcal vaccines developed autoantibodies with affinities for different tissues (smooth muscle, cytoplasmic, and myocardial antibodies) and for autologous proteins (anti-albumin and anti-immunoglobulin antibodies). The presence of anti-albumin and smooth muscle antibodies, associated with a high level of immunoglobulin, suggests the development of hepatic disorders in the hyperimmunized rabbits.
摘要
用A、C和G组链球菌疫苗进行超免疫的兔子产生了对不同组织（平滑肌、细胞质和心肌抗体）以及自体蛋白（抗白蛋白和抗免疫球蛋白抗体）具有亲和力的自身抗体。抗白蛋白和平滑肌抗体的存在，与高水平的免疫球蛋白相关，提示超免疫兔子出现了肝脏疾病。
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