甲状腺切除术后与疲乏相关的健康相关生活质量的患者报告结局测量指标。

Patient Reported Outcome Measures of Health-Related Quality of Life and Asthenia after Thyroidectomy.

机构信息

College of Medicine, University of Nebraska, Omaha, Nebraska.

Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, Nebraska.

出版信息

J Surg Res. 2021 Aug;264:394-401. doi: 10.1016/j.jss.2021.02.039. Epub 2021 Apr 10.

DOI:10.1016/j.jss.2021.02.039

PMID:33848838

Abstract

BACKGROUND

After thyroidectomy some patients experience a chronic fatigue syndrome called asthenia. The purpose of this study was to determine the post-operative health related quality of life (HRQOL) and risk of asthenia in patients undergoing thyroidectomy.

METHODS

A single institution prospective observational cohort study of adults undergoing thyroidectomy from September 2016 to July 2019 with four HRQOL surveys: preoperative baseline, 2 wk-, 6 mo- and 12 mo-postoperatively. Patients were surveyed using the Short Form 36 version 2 and Brief Fatigue Inventory. Asthenia was defined as Brief Fatigue Inventory > 60 at 12 mo. HRQOL was compared between patients undergoing thyroid lobectomy (TL) or total thyroidectomy (TT) with benign (-B) or malignant (-Ca) final pathology.

RESULTS

A total of 182 patients were included: 67 (37%) with TL-B, 32 (17%) with TL-Ca, 40 (22%) with TT-B, and 43 (24%) with TT-Ca. The incidence of asthenia was 42% for TT and 4% for TL. In the TL-B group, 2 patients (3%) developed asthenia, compared with 2 patients (6.25%) in the TL-Ca group, 14 patients (35%) in the TT-B group, and 21 (48.8%) in the TT-Ca group (P = 0.0001). The odds ratio of asthenia for TT compared to TL was 10.4 (95% CI 3.86-28.16) and for patients with malignancy compared to benign disease was 2.05 (95% CI 1.17-3.61).

CONCLUSIONS

Patients undergoing TT have a higher risk of developing asthenia than those undergoing TL, particularly if the final pathology shows malignancy.

摘要

背景

甲状腺切除术后，一些患者会出现慢性疲劳综合征，称为乏力。本研究旨在确定行甲状腺切除术患者的术后健康相关生活质量（HRQOL）和乏力风险。

方法

这是一项单中心前瞻性观察队列研究，纳入 2016 年 9 月至 2019 年 7 月期间行甲状腺切除术的成年人，共进行了 4 次 HRQOL 调查：术前基线、术后 2 周、6 个月和 12 个月。使用简明 36 项健康调查量表第 2 版和简短疲劳量表对患者进行调查。12 个月时使用简短疲劳量表评分>60 定义为乏力。比较甲状腺叶切除术（TL）或全甲状腺切除术（TT）与良性（-B）或恶性（-Ca）最终病理患者的 HRQOL。

结果

共纳入 182 例患者：67 例（37%）行 TL-B、32 例（17%）行 TL-Ca、40 例（22%）行 TT-B 和 43 例（24%）行 TT-Ca。乏力的发生率为 TT 组 42%，TL 组 4%。在 TL-B 组中，2 例（3%）患者出现乏力，TL-Ca 组 2 例（6.25%），TT-B 组 14 例（35%），TT-Ca 组 21 例（48.8%）（P=0.0001）。与 TL 相比，TT 发生乏力的比值比为 10.4（95%CI 3.86-28.16），与良性疾病相比，恶性疾病的比值比为 2.05（95%CI 1.17-3.61）。