Vijayakumar K, Rengarajan R L, Suganthi N, Prasanna B, Velayuthaprabhu S, Shenbagam M, Vijaya Anand A
Department of Chemistry, Sri Meenakshi Vidiyal Arts and Science College, Tiruchirappalli, India.
Department of Animal Science, Bharathidasan University, Tiruchirappalli, India.
Drug Chem Toxicol. 2022 Sep;45(5):2086-2096. doi: 10.1080/01480545.2021.1907908. Epub 2021 Apr 13.
The medicinal properties of () bark have been reported for their clinical importance for many diseases including diabetes. However, there is no clear evidence so far regarding dose selection for its hepato- and nephroprotective effect in diabetic condition. Hence, the present study aims at evaluating antioxidant activity, the acute toxicity, and dose fixation of bark for their effective medicinal values in streptozotocin (STZ)-induced rats. All the extracts exhibited potential antioxidant activity and showed a dose-dependent (1000, 2000, 3000, 4000, and 5000 mg/kg BW) acute toxicity by model. The levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), urea, and creatinine showed a significant elevation in animals treated with the highest dose. In further studies along with histopathological studies, animals treated with STZ (60 mg/kg BW) followed by a different dose (300, 400, and 500 mg/kg BW) of ethanolic extract of the bark and glibenclamide (3 mg/kg BW) revealed that the altered level of mitochondrial enzymes, hepatic, and renal marker in STZ-induced animals were restored in bark extract-treated group as of control. These results could be of scientific support for the use of the ethanolic extract of the bark in folk medicine for the management of diabetes and its associated complications.
（）树皮的药用特性因其对包括糖尿病在内的多种疾病的临床重要性而被报道。然而，迄今为止，关于其在糖尿病状态下对肝脏和肾脏的保护作用的剂量选择尚无明确证据。因此，本研究旨在评估（）树皮的抗氧化活性、急性毒性以及确定其在链脲佐菌素（STZ）诱导的大鼠中的有效药用价值的剂量。所有提取物均表现出潜在的抗氧化活性，并通过（）模型显示出剂量依赖性（1000、2000、3000、4000和5000mg/kg体重）的急性毒性。在用最高剂量处理的动物中，天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、尿素和肌酐水平显著升高。在进一步的研究以及组织病理学研究中，用STZ（60mg/kg体重）处理后再给予不同剂量（300、400和500mg/kg体重）的（）树皮乙醇提取物和格列本脲（3mg/kg体重）处理的动物显示，在树皮提取物处理组中，STZ诱导动物中线粒体酶、肝脏和肾脏标志物的改变水平恢复到了与对照组相当的水平。这些结果可为民间医学中使用（）树皮乙醇提取物治疗糖尿病及其相关并发症提供科学支持。
