Departments of Internal Medicine "C", "D" & "E" and Institute for Special Medical Examinations (MALRAM), Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Laboratory of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, 6423906, Tel-Aviv, Israel.
BMC Pulm Med. 2021 Apr 13;21(1):119. doi: 10.1186/s12890-021-01488-5.
High serum bilirubin levels have been shown to be associated with an improved pulmonary function test results. Their potential ability to similarly benefit pulmonary function in an environment of polluted air has not been tested. We retrospectively analyzed data of 15,605 apparently healthy individuals in order to evaluate the effect of serum bilirubin levels on forced expiratory volume in 1 s (FEV1).
Individuals attended the Tel-Aviv Medical Center Inflammatory Survey for a routine annual health check between February, 2002 and June, 2009 and were divided into low, medium and high serum bilirubin levels. Their FEV1 results were compared under various levels of air pollution. Air pollution and weather data were obtained from air pollution monitoring stations of the Israeli Ministry of Environmental Protection.
The elevated serum bilirubin concentrations on FEV1 were evaluated under moderate and high pollution levels FEV1 and were significantly higher in participants with high blood bilirubin levels compared to medium or low levels (p < 0.001 and p = 0.018, respectively). Participants with high levels of bilirubin had preserved FEV1 under exposure to high and medium pollution levels of both Nitrogen Oxide (NOx) and Carbon Monoxide (CO) pollutants (p = 0.003 and p = 0.022, respectively). The multivariate regression analysis revealed that the influence of bilirubin under conditions of air pollution remained significant even after adjustment for FEV1 confounders, but the interaction was not significant.
Elevated serum bilirubin concentrations are associated with preserved lung function in healthy individuals in Israel exposed to high levels of air pollution.
高血清胆红素水平与改善肺功能测试结果有关。尚未测试其在污染空气环境中同样有益于肺功能的潜在能力。我们回顾性分析了 15605 名显然健康个体的数据，以评估血清胆红素水平对 1 秒用力呼气量（FEV1）的影响。
个体于 2002 年 2 月至 2009 年 6 月期间在特拉维夫医疗中心炎症调查中参加常规年度健康检查，并根据血清胆红素水平分为低、中、高三组。在不同水平的空气污染下比较他们的 FEV1 结果。空气污染和天气数据是从以色列环境保护部的空气污染监测站获得的。
在中、高污染水平下评估了 FEV1 时升高的血清胆红素浓度，与中或低胆红素水平的参与者相比，高胆红素水平的参与者的 FEV1 明显更高（分别为 p < 0.001 和 p = 0.018）。在接触高和中污染水平的氮氧化物（NOx）和一氧化碳（CO）污染物时，胆红素水平高的参与者的 FEV1 保持不变（分别为 p = 0.003 和 p = 0.022）。多元回归分析表明，即使在调整 FEV1 混杂因素后，胆红素在空气污染条件下的影响仍然显著，但交互作用不显著。
在以色列暴露于高水平空气污染的健康个体中，升高的血清胆红素浓度与肺功能正常有关。
