Borro Matteo, Negrini Simone, Long Andrew, Chinthrajah Sharon, Murdaca Giuseppe
Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Grant Building, S093, 300 Pasteur Dr., Stanford, CA, 94305-5101, USA.
Clin Mol Allergy. 2021 Apr 13;19(1):4. doi: 10.1186/s12948-021-00143-y.
Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H-receptor antagonist in allergic reactons.
组胺是一种由氨基酸组氨酸合成的单胺，因其在IgE介导的过敏反应中的作用而闻名，但已显示出对免疫系统具有多效性作用，尤其是为了促进炎症反应。H受体拮抗剂是用于轻度/中度过敏反应的常用药物，而H受体拮抗剂通常用于治疗胃溃疡，但在过敏方面也有一些特性。欧洲变态反应和临床免疫学会（EAACI）关于过敏反应诊断和治疗的指南建议将其作为H拮抗剂辅助治疗的三线疗法。本文的目的是对迄今为止已知的关于H受体拮抗剂在过敏反应中的有用性的研究结果和证据进行完整总结。
