低蛋白血症预测 COVID-19 疾病严重程度和死亡率：呼吁采取行动。
Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action.
机构信息
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Psychiatric Nursing and Mental Health, Faculty of Nursing, Alexandria University, Alexandria, Egypt.
出版信息
Diagn Pathol. 2021 Apr 13;16(1):31. doi: 10.1186/s13000-021-01092-5.
Abstract
Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.
摘要
蛋白质是身体组织的主要构成部分，它们调节着大多数细胞活动中涉及的信号转导。2019 年冠状病毒病（COVID-19）感染的死亡率很高，尤其是在老年人中。死亡的主要原因是肺组织损伤和多器官衰竭。该疾病与一种高分解代谢状态有关，会导致蛋白质过度流失。本评论文章重点探讨了有症状/住院 COVID-19 患者低蛋白血症的病理生理学、筛查以及其对疾病严重程度和不良后果的影响。
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