MacCallum P K, Freemont A J, Geary C G, Liu Yin J A
University Department of Haematology, Manchester Royal Infirmary.
J Clin Pathol. 1988 May;41(5):486-9. doi: 10.1136/jcp.41.5.486.
A case of IgD myeloma accompanied by diffuse osteosclerosis is reported. A trephine biopsy specimen showed only reticulin fibrosis, but histomorphometric analysis of a full thickness transiliac bone biopsy specimen showed increased trabecular bone mass, with no local deposit of tumour. An excess of bone surfaces were covered by osteoid seams, all of which showed active mineralisation, indicating a relative increase in osteoblastic activity; osteoclasis seemed to be unaffected. It is suggested that the cause of the generalised osteosclerosis might be production of an osteoblast stimulating factor by the myeloma cells.
报告了1例伴有弥漫性骨硬化的IgD骨髓瘤病例。环钻活检标本仅显示网状纤维组织增生，但对全层髂骨活检标本进行组织形态计量学分析显示小梁骨量增加，无肿瘤局部沉积。过多的骨表面被类骨质缝覆盖，所有类骨质缝均显示活跃矿化，表明成骨细胞活性相对增加；破骨作用似乎未受影响。提示全身骨硬化的原因可能是骨髓瘤细胞产生了一种成骨细胞刺激因子。
