Huber A M, Wallins L L, DeRusso P
Department of Nutrition, Simmons College, Boston.
J Am Diet Assoc. 1988 Jul;88(7):791-5.
Folacin intakes from diet and supplements consumed during pregnancy were determined by interview in 566 women. Eight percent of this population (48 women) obtained folacin from diet only. Thirteen percent (76 women) received less than two-thirds of the RDA for folacin for pregnant women. Serum and erythrocyte folate levels in maternal and cord blood were correlated with dietary folacin intakes in subsamples of the group. Women who received their folate from diet alone showed marginal or deficient maternal serum folate levels. Of the group of women whose folacin intake was equal to or greater than the RDA for pregnant women, some had intakes as high as eight times the RDA from supplements. When, in a subsample, total folacin intake was correlated with maternal and cord folate levels, significant correlations were obtained. The high serum and erythrocyte folate levels resulting from self-medication with folate supplements are of concern because of possible deleterious interaction with other nutrients.
