超高场层切 fMRI 人类大脑实验方案
A protocol for ultra-high field laminar fMRI in the human brain.
机构信息
Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
出版信息
STAR Protoc. 2021 Mar 26;2(2):100415. doi: 10.1016/j.xpro.2021.100415. eCollection 2021 Jun 18.
Ultra-high field (UHF) neuroimaging affords the sub-millimeter resolution that allows researchers to interrogate brain computations at a finer scale than that afforded by standard fMRI techniques. Here, we present a step-by-step protocol for using UHF imaging (Siemens Terra 7T scanner) to measure activity in the human brain. We outline how to preprocess the data using a pipeline that combines tools from SPM, FreeSurfer, ITK-SNAP, and BrainVoyager and correct for vasculature-related confounders to improve the spatial accuracy of the fMRI signal. For complete details on the use and execution of this protocol, please refer to Jia et al. (2020) and Zamboni et al. (2020).
超高场（UHF）神经影像学提供了亚毫米级的分辨率，使研究人员能够以前所未有的精细尺度研究大脑的计算。在这里，我们提供了一个使用 UHF 成像（西门子 Terra 7T 扫描仪）测量人类大脑活动的分步协议。我们概述了如何使用一个结合了 SPM、FreeSurfer、ITK-SNAP 和 BrainVoyager 工具的管道来预处理数据，并纠正与血管相关的混杂因素，以提高 fMRI 信号的空间精度。有关此协议的使用和执行的完整详细信息，请参阅 Jia 等人（2020 年）和 Zamboni 等人（2020 年）。
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