Clarkson P M, Dedrick M E
Department of Exercise Science, University of Massachusetts.
J Gerontol. 1988 Jul;43(4):M91-6. doi: 10.1093/geronj/43.4.m91.
This study examined exercise-induced muscle damage, repair, and adaptation in 10 college age women and 10 women over age 60. On two sessions spaced 7 days apart, subjects performed an eccentric exercise of the forearm flexors consisting of 24 muscle actions at an intensity of 115% of isometric strength. Serum creatine kinase activity, flexed and relaxed elbow joint angles, and muscle pain were assessed prior to and for 5 days after each exercise session. The exercise resulted in similar changes in CK, muscle pain, and inability to fully flex the forearm for old and young subjects. The old group demonstrated greater muscle shortening (a decrease in the relaxed elbow joint angle). The old and young groups adapted to the first exercise such that changes in all criterion measures were reduced following the second exercise. For the physically active subjects in this study, the damage process (with the exception of muscle shortening) takes a similar course for old and young. The repair process is equally as effective in old and young, and older subjects show the same ability to adapt to the damage as young subjects.
本研究对10名大学年龄女性和10名60岁以上女性的运动诱导肌肉损伤、修复和适应情况进行了检查。在间隔7天的两次实验中，受试者进行了前臂屈肌的离心运动，包括24次肌肉动作，强度为等长力量的115%。在每次运动前及运动后5天评估血清肌酸激酶活性、屈肘和伸肘关节角度以及肌肉疼痛情况。运动导致老年和年轻受试者的肌酸激酶、肌肉疼痛以及前臂无法完全屈曲的情况出现相似变化。老年组表现出更大程度的肌肉缩短（伸肘关节角度减小）。老年组和年轻组对第一次运动产生了适应性变化，使得第二次运动后所有标准测量指标的变化都有所减少。对于本研究中的身体活跃受试者，老年和年轻个体的损伤过程（肌肉缩短除外）相似。老年和年轻个体的修复过程同样有效，并且老年受试者与年轻受试者表现出相同的损伤适应能力。
