在症状轻微的个体中持续存在有复制能力的 SARS-CoV-2：两例病例报告。
Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A report of two cases.
机构信息
Laboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Departamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
出版信息
J Med Virol. 2021 Sep;93(9):5603-5607. doi: 10.1002/jmv.27021. Epub 2021 Apr 23.
Abstract
It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of 20 days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset.
摘要
据估计，COVID-19 患者在症状出现后最多可排出复制能力的病毒长达 20 天。大多数涉及这种情况的研究都涉及住院患者和重症患者。针对轻度感染个体在 COVID-19 疾病的不同阶段可能存在 SARS-CoV-2 以及利用病毒培养技术鉴定复制能力病毒的研究受到限制。本报告描述了两例轻度疾病患者，他们分别在症状出现后 24 天和 37 天排出复制能力的病毒。
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