Protocol Optimization Considerations for Implementing Deep Learning CT Reconstruction.

Previous advances over filtered back projection (FBP) have incorporated model-based iterative reconstruction. The purpose of this study was to characterize the latest advance in image reconstruction, that is, deep learning. The focus was on applying characterization results of a deep learning approach to decisions about clinical CT protocols. A proprietary deep learning image reconstruction (DLIR) method was characterized against an existing advanced adaptive statistical iterative reconstruction method (ASIR-V) and FBP from the same vendor. The metrics used were contrast-to-noise ratio, spatial resolution as a function of contrast level, noise texture (i.e., noise power spectra [NPS]), noise scaling as a function of slice thickness, and CT number consistency. The American College of Radiology accreditation phantom and a uniform water phantom were used at a range of doses and slice thicknesses for both axial and helical acquisition modes. ASIR-V and DLIR were associated with improved contrast-to-noise ratio over FBP for all doses and slice thicknesses. No dose or contrast dependencies of spatial resolution were observed for ASIR-V or DLIR. NPS results showed DLIR maintained an FBP-like noise texture whereas ASIR-V shifted the NPS to lower frequencies. Noise changed with dose and slice thickness in the same manner for ASIR-V and FBP. DLIR slice thickness noise scaling differed from FBP, exhibiting less noise penalty with decreasing slice thickness. No clinically significant changes were observed in CT numbers for any measurement condition. In a phantom model, DLIR does not suffer from the concerns over reduction in spatial resolution and introduction of poor noise texture associated with previous methods.