梅尼埃病中的甲状腺功能障碍：全面综述。
Thyroid Dysfunction in Ménière's Disease: A Comprehensive Review.
机构信息
College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA.
Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA.
出版信息
ORL J Otorhinolaryngol Relat Spec. 2021;83(4):219-226. doi: 10.1159/000514792. Epub 2021 Apr 14.
INTRODUCTION
The precise etiology of Ménière's disease (MD) remains unknown; however, given the association of MD with serum antibodies and human leukocyte antigen (HLA) complex, several studies have proposed a relationship between MD and thyroid disorders. Similarly, multiple hypotheses exist regarding the metabolic disturbances of fluctuating thyroid hormone as a potential contributing agent in the development of MD.
METHODS
A total of 171 abstracts were identified and screened by 2 independent reviewers. Based on inclusion and exclusion criteria, 8 studies were selected for final analysis. Due to heterogeneity of clinical data, meta-analysis was not feasible.
RESULTS
The prevalence of autoimmune thyroid disease and hypothyroidism in MD varied significantly from 1 to 38%. Notable bias was introduced given the lack of standardization of diagnostic criteria across studies. Articles that described autoimmune thyroid-specific antibodies and HLA types also presented inconclusive results. Multiple studies noted a potential etiologic role of hypothyroidism in MD, which was often confounded by thyroxine supplementation.
CONCLUSIONS
Despite a potential correlation in the medical literature between thyroid disorders and MD, there is currently no definitive causal relationship. Although most of the present medical literature focuses on autoimmunity, dysregulated thyroid hormone levels may also be implicated in the association of MD with thyroid disorders.
简介
梅尼埃病（MD）的确切病因仍不清楚；然而，鉴于 MD 与血清抗体和人类白细胞抗原（HLA）复合物有关，一些研究提出了 MD 与甲状腺疾病之间的关系。同样，关于甲状腺激素波动的代谢紊乱作为 MD 发展的潜在致病因素也存在多种假说。
方法
通过 2 名独立评审员共识别和筛选了 171 篇摘要。根据纳入和排除标准，最终选择了 8 项研究进行分析。由于临床数据存在异质性，因此无法进行荟萃分析。
结果
MD 中自身免疫性甲状腺疾病和甲状腺功能减退症的患病率差异显著，为 1%至 38%。由于缺乏 across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across across
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