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转化生长因子β信号在主动脉平滑肌细胞中的缺失导致内皮功能障碍和主动脉高收缩性。

Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility.

机构信息

Surgery (J.Z.), University of Washington, Seattle.

Departments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.

出版信息

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1956-1971. doi: 10.1161/ATVBAHA.121.315878. Epub 2021 Apr 15.

DOI:10.1161/ATVBAHA.121.315878
PMID:33853348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8159907/
Abstract

[Figure: see text].

摘要

[图：见正文]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/d0e16d87a9ba/nihms-1692870-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/e3500bebc0d5/nihms-1692870-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/81f90c1c1e78/nihms-1692870-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/ffa1f2600ab3/nihms-1692870-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/426e70b1c2fa/nihms-1692870-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/90cd502227f0/nihms-1692870-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/9ea51ed59df2/nihms-1692870-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/d0e16d87a9ba/nihms-1692870-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/e3500bebc0d5/nihms-1692870-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/81f90c1c1e78/nihms-1692870-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/ffa1f2600ab3/nihms-1692870-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/426e70b1c2fa/nihms-1692870-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/90cd502227f0/nihms-1692870-f0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64f/8159907/d0e16d87a9ba/nihms-1692870-f0007.jpg

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本文引用的文献

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2
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Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.心血管疾病中的内皮细胞向间充质细胞转化：JACC 前沿综述。
成年小鼠体内转化生长因子-β（TGF-β）信号的短期中断会使主动脉易受高血压诱导的夹层影响。
JCI Insight. 2025 Feb 11;10(6):e182629. doi: 10.1172/jci.insight.182629.
4
Fibrillin-1 Deficiency Perturbs Aortic Cholinergic Relaxation and Adrenergic Contraction in a Mouse Model of Early Onset Progressively Severe Marfan Syndrome.在早发性进行性重度马凡综合征小鼠模型中，原纤维蛋白-1缺乏扰乱主动脉胆碱能舒张和肾上腺素能收缩。
J Vasc Res. 2025;62(2):96-108. doi: 10.1159/000542481. Epub 2025 Jan 17.
5
Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells.通过诱导多能干细胞视角理解胸主动脉疾病的基因组医学。
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