Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, United States.
Department of Psychology, University of Pittsburgh, Pittsburgh, United States.
Ethn Health. 2022 Oct;27(7):1599-1615. doi: 10.1080/13557858.2021.1913484. Epub 2021 Apr 14.
Investigate the associations between self-reported physical activity (PA) engagement and white matter (WM) health (i.e. volume, integrity, and hyperintensities) in older Latinos.
Cross-sectional study with community-dwelling older adults from predominantly Latino neighborhoods. Thirty-four cognitively healthy older Latinos from two different cohorts. Participants self-reported demographic information, PA engagement [Community Healthy Activities Model Program for Seniors (CHAMPS) Physical Activity Questionnaire for Older Adults] and magnetic resonance imaging (MRI). We used high-resolution three-dimensional T1- and T2-FLAIR weighted images and diffusion tensor imaging acquired via 3 T MRI. We performed a series of hierarchical linear regression models with the addition of relevant covariates to examine the associations between self-reported PA levels and WM volume, integrity, and hyperintensities (separately). We adjusted -values with the use of the Benjamini-Hochberg's false discovery rate procedure.
Higher reported levels of leisure-time moderate-to-vigorous PA were significantly associated with higher WM volume of the posterior cingulate (β = 0.220, SE = 0.125, 95% CI 0.009-0.431, = 0.047) and isthmus cingulate (β = 0.212, SE = 0.110, 95% CI 0.001-0.443, = 0.044) after controlling for intracranial volume. Higher levels of total PA were significantly associated with higher overall WM volume of these same regions (posterior cingulate: β = 0.220, SE = 0.125, CI 0.024-0.421, = 0.046; isthmus cingulate: β = 0.220, SE = 0.125, 95% CI 0.003-0.393; = 0.040). Significant -values did not withstand Benjamini-Hochberg's adjustment. PA was not significantly associated with WM integrity or WM hyperintensities.
Higher levels of PA, particularly higher leisure-time moderate-to-vigorous PA, might be associated with greater WM volume in select white matter regions key to brain network integration for physical and cognitive functioning in older Latinos. More research is needed to further confirm these associations.
调查自述体力活动（PA）参与情况与老年拉丁裔人群的白质（WM）健康（即体积、完整性和高信号）之间的关联。
来自以拉丁裔为主的社区的社区居住的老年成年人的横断面研究。来自两个不同队列的 34 名认知健康的老年拉丁裔人。参与者自我报告人口统计学信息、PA 参与情况（社区健康活动模式计划为老年人（CHAMPS）老年人体力活动问卷）和磁共振成像（MRI）。我们使用高分辨率三维 T1-和 T2-FLAIR 加权图像以及通过 3T MRI 获得的扩散张量成像。我们进行了一系列分层线性回归模型，并加入了相关协变量，以分别检查自我报告的 PA 水平与 WM 体积、完整性和高信号之间的关联。我们使用 Benjamini-Hochberg 的错误发现率程序调整了 值。
较高水平的休闲时间中度至剧烈 PA 与后扣带（β=0.220，SE=0.125，95%CI 0.009-0.431，=0.047）和峡部扣带（β=0.212，SE=0.110，95%CI 0.001-0.443，=0.044）的 WM 体积较高显著相关，在控制颅内体积后。较高的总 PA 水平与这些相同区域的整体 WM 体积较高显著相关（后扣带：β=0.220，SE=0.125，CI 0.024-0.421，=0.046；峡部扣带：β=0.220，SE=0.125，95%CI 0.003-0.393；=0.040）。显著的 值在 Benjamini-Hochberg 的调整后无法维持。PA 与 WM 完整性或 WM 高信号无显著相关性。
较高水平的 PA，特别是较高的休闲时间中到剧烈的 PA，可能与老年拉丁裔人群特定的 WM 区域的 WM 体积较大有关，这些区域对身体和认知功能的大脑网络整合至关重要。需要进一步的研究来进一步证实这些关联。
