2-氧杂螺[4.5]癸烷和 -吡咯尼辛衍生物来自内生真菌 PSU-H51。
2-Oxaspiro[4.5]decane and -pyrenocine derivatives from the endophytic fungus sp. PSU-H51.
机构信息
Faculty of Science and Technology, Suratthani Rajabhat University, Surat Thani, Thailand.
Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand.
出版信息
Nat Prod Res. 2022 Oct;36(19):4911-4920. doi: 10.1080/14786419.2021.1910692. Epub 2021 Apr 14.
One new 2-oxaspiro[4.5]decane, roussoellide, and one new pyrenocine, 2,3-dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E, were obtained from the culture broth of the endophytic fungus sp. Their structures were determined using spectroscopic data. The absolute configuration of known arthropsolide A was assigned on the basis of X-ray diffraction data using Cu K radiation. Known pyrenocine A displayed weak cytotoxic activity against breast cancer (MCF-7) cells with an IC value of 27.1M and weak antifungal activity against SH-MU-4 with an MIC value of 615.2M.[Formula: see text].
从内生真菌 sp 的发酵液中分离得到一个新的 2-氧杂螺[4.5]癸烷、 Roussoellide 和一个新的吡喃诺辛、2,3-二氢吡喃诺辛 A，以及包括已知的 Arthropsolide A 和吡喃诺辛 A 和 E 在内的 9 种已知化合物。采用光谱数据确定了它们的结构。根据 X 射线衍射数据，使用 Cu K 辐射确定了已知 Arthropsolide A 的绝对构型。已知的吡喃诺辛 A 对乳腺癌（MCF-7）细胞表现出较弱的细胞毒性，IC 值为 27.1M，对 SH-MU-4 表现出较弱的抗真菌活性，MIC 值为 615.2M。[化学式：见正文]。
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