Sommart Ubonta, Rukachaisirikul Vatcharin, Sukpondma Yaowapa, Phongpaichit Souwalak, Sakayaroj Jariya, Kirtikara Kanyawim
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkla, Thailand.
Chem Pharm Bull (Tokyo). 2008 Dec;56(12):1687-90. doi: 10.1248/cpb.56.1687.
Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum SH-MU-4 with a minimum inhibitory concentration (MIC) value of 2 microg/ml while all metabolites exhibited very weak antibacterial activity (MIC value>or=128 microg/ml) against Staphylococcus aureus, both standard and methicillin-resistant strains. 3-(2-Hydroxypropyl)benzene-1,2-diol (10) showed moderate antimalarial activity against Plasmodiun falciparum with an IC(50) value of 6.68 microg/ml. For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value of 12.50 microg/ml.
从内生真菌PSU-N24中分离出三种新的氢化萘酮衍生物（1-3）和一种新的二氢拉美洛辛衍生物（4），以及八种已知化合物。通过光谱方法阐明了它们的结构。灰黄霉素（9）对石膏样小孢子菌SH-MU-4显示出强抗真菌活性，最低抑菌浓度（MIC）值为2微克/毫升，而所有代谢产物对金黄色葡萄球菌（包括标准菌株和耐甲氧西林菌株）均表现出非常弱的抗菌活性（MIC值≥128微克/毫升）。3-(2-羟丙基)苯-1,2-二醇（10）对恶性疟原虫显示出中等抗疟活性，IC50值为6.68微克/毫升。对于抗结核分枝杆菌活性，化合物3表现出最佳活性，MIC值为12.50微克/毫升。
