Jia Yujiao, Song Tiantian, Li Zelin, Zhou Linling, Chen Shuchun
Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Feb 19;15:511-525. doi: 10.2147/DMSO.S348845. eCollection 2022.
The study aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH) D] and triglyceride glucose index (TyG) levels in male and female patients with type 2 diabetes mellitus (T2DM).
This cross-sectional study recruited 592 patients with type 2 diabetes. The subjects were divided into the non-vitamin D deficiency group [25(OH)D≥20ng/mL] and the vitamin D deficiency group [25(OH)D<20ng/mL]. The triglyceride glucose (TyG) index is calculated using the following formula, ln[fasting triglycerides (mg/dL)*fasting blood glucose (mg/dL)/2]. Participants were divided into high TyG group and low TyG group, with the median of TyG as the boundary. All participants were divided into male and female groups and normal Body mass index (BMI) and high BMI groups, and then divided into high TyG group and low TyG group.
We found that TyG levels are independently and negatively correlated with vitamin D levels in male patients with T2DM. In the female group, there was no significant correlation between TyG and vitamin D levels, regardless of an adjusted or unadjusted confounding factor. Subgroup analysis showed that the correlation between TyG and the risk of vitamin D deficiency in the normal BMI group was significantly stronger than that in the high BMI group.
This study indicates that vitamin D deficiency is related to high TyG level in patients with T2DM for males, and this relationship is not significant for female patients. The risk of vitamin D deficiency is significantly correlated with high TyG level in normal BMI group. However, there was no statistically significant difference between TyG level and the risk of vitamin D deficiency in the high BMI group. Difference between TyG level and the risk of vitamin D deficiency.
本研究旨在探讨2型糖尿病（T2DM）男性和女性患者中25-羟基维生素D [25(OH)D]与甘油三酯葡萄糖指数（TyG）水平之间的关系。
这项横断面研究招募了592例2型糖尿病患者。研究对象被分为非维生素D缺乏组[25(OH)D≥20ng/mL]和维生素D缺乏组[25(OH)D<20ng/mL]。甘油三酯葡萄糖（TyG）指数采用以下公式计算，ln[空腹甘油三酯（mg/dL）*空腹血糖（mg/dL）/2]。参与者以TyG的中位数为界分为高TyG组和低TyG组。所有参与者又被分为男性组和女性组，以及正常体重指数（BMI）组和高BMI组，然后再分为高TyG组和低TyG组。
我们发现，T2DM男性患者中TyG水平与维生素D水平呈独立负相关。在女性组中，无论是否调整混杂因素，TyG与维生素D水平之间均无显著相关性。亚组分析显示，正常BMI组中TyG与维生素D缺乏风险的相关性显著强于高BMI组。
本研究表明，维生素D缺乏与T2DM男性患者的高TyG水平相关，而这种关系在女性患者中不显著。正常BMI组中维生素D缺乏风险与高TyG水平显著相关。然而，高BMI组中TyG水平与维生素D缺乏风险之间无统计学显著差异。TyG水平与维生素D缺乏风险之间的差异。
