El-Baz Farouk K, Elgohary Rania, Salama Abeer
Plant Biochemistry Department, National Research Centre (NRC), 33 El Buhouth St., Dokki, Cairo 12622, Egypt.
Narcotics, Ergogenics and Poisons Department, National Research Centre (NRC), 33 El Buhouth St., Dokki, Cairo 12622, Egypt.
Biomed Res Int. 2021 Mar 28;2021:8843218. doi: 10.1155/2021/8843218. eCollection 2021.
Hepatic encephalopathy (HE) is a neuropsychiatric disease that is developed as a complication of both acute and chronic liver failure affecting psychomotor dysfunction, memory, and concentration. This study is aimed at evaluating the therapeutic effects of (. ) microalgae in thioacetamide- (TAA-) induced HE in rats. HE was induced by TAA (200 mg/kg; i.p.) for three successive days. Forty male Wister albino rats were divided into 4 groups; the first group was served as a normal, and the second group was injected with TAA and served as TAA control. The third and fourth groups were administered . (100 and 200 mg/kg; p.o.), respectively, after TAA injection for 7 days. The behavioral and biochemical markers as well as histological aspects of HE were estimated. This study revealed that TAA caused behavioral changes, oxidative stress, neuroinflammation, nuclear pyknosis, and neurons degeneration. improved liver function and decreased oxidative stress and inflammatory mediator as TLR4 protein expression. Also, . elevated HSP-25 and IGF-1 as well as improved brain histopathological alterations. In conclusion, . exerted a therapeutic potential against HE via its antioxidant, antiinflammatory and cytoprotective effects.
肝性脑病（HE）是一种神经精神疾病，作为急性和慢性肝功能衰竭的并发症而出现，会影响精神运动功能、记忆力和注意力。本研究旨在评估（.）微藻对硫代乙酰胺（TAA）诱导的大鼠肝性脑病的治疗效果。连续三天腹腔注射TAA（200mg/kg）诱导肝性脑病。40只雄性Wister白化大鼠分为4组；第一组作为正常组，第二组注射TAA作为TAA对照组。第三组和第四组在注射TAA 7天后分别口服（.）（100mg/kg和200mg/kg）。评估了肝性脑病的行为和生化指标以及组织学特征。本研究表明，TAA会引起行为改变、氧化应激、神经炎症、核固缩和神经元变性。（.）改善了肝功能，降低了氧化应激和炎症介质如TLR4蛋白表达。此外，（.）提高了HSP-25和IGF-1水平，并改善了脑组织病理学改变。总之，（.）通过其抗氧化、抗炎和细胞保护作用对肝性脑病发挥了治疗潜力。
