Department of Radiology, Institute for Image Guided Therapy, Rinku Ohrai-mimami, Izumisano, Osaka, Japan.
Jpn J Clin Oncol. 2021 May 28;51(6):851-856. doi: 10.1093/jjco/hyab050.
Previous reports on transarterial treatment for lung cancer were reviewed. The bronchial arterial infusion therapy has a long history since 1964. Better local control with less doses of anti-neoplastic agents was warranted by trying transarterial administration to lung and mediastinal tumors. It is reported that both primary and metastatic tumors are fed by bronchial or other systemic arteries. The bronchial arterial embolization for hemoptysis has been introduced for clinical practice since 1973. Hemoptysis by not only benign but also malignant diseases has been well controlled by embolization. In recent decades, the technical elements for transarterial treatments have markedly improved. They make it possible to carry out precise procedures of selective catheter insertion to the tumor relating arteries. Current concepts of transarterial treatment, technical aspects and treatment outcomes are summarized. Tentative result from chemo-embolization for advanced lung cancer using recent catheter techniques was also described. It provides favorable local control and survival merits. It is considered that a population of lung cancer patients can benefit from transarterial management using small doses of anti-neoplastic agents, with less complications and less medical costs.
回顾了经动脉治疗肺癌的既往报告。自 1964 年以来，支气管动脉灌注疗法已有很长的历史。通过尝试向肺部和纵隔肿瘤进行经动脉给药，可以更好地控制局部并减少抗肿瘤药物的剂量。据报道，原发性和转移性肿瘤均由支气管或其他体循环动脉供应。1973 年以来，支气管动脉栓塞治疗咯血已应用于临床实践。栓塞不仅可以控制良性疾病引起的咯血，也可以控制恶性疾病引起的咯血。近几十年来，经动脉治疗的技术要素有了显著改善。这使得能够对肿瘤相关动脉进行精确的选择性导管插入术。总结了经动脉治疗的当前概念、技术方面和治疗结果。还描述了使用最近的导管技术对晚期肺癌进行化疗栓塞的初步结果。它提供了有利的局部控制和生存获益。考虑到使用小剂量抗肿瘤药物、减少并发症和降低医疗费用，通过经动脉管理可以使一部分肺癌患者受益。
