Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Department of Joint and Trauma Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
ACS Appl Mater Interfaces. 2021 Apr 28;13(16):18488-18499. doi: 10.1021/acsami.1c00553. Epub 2021 Apr 15.
The postoperative tumor recurrence and chemotherapy resistance in clinical osteosarcoma treatment have raised an imperative need to develop local implants for selectively killing residual tumor cells and simultaneously provide a scaffold for effectively filling the tumor resection-induced bone defects. Herein, a multifunctional platform is developed through successively coating TiN microparticles and doxorubicin (DOX) on the surface of tricalcium phosphate (TCP) scaffolds to achieve synergetic effects of photothermal therapy and chemotherapy for osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted by immersing the scaffolds into the solution containing different concentrations of TiN and DOX. The excellent therapeutic effect was achieved both and through the precise photothermal therapy and localized controlled-release chemotherapy. Moreover, the overall bulk scaffolds provide the mechanical support for bone tissue when implanting scaffolds into bone defects resulting from surgical removal of osteosarcoma. Importantly, using the poly(d,l-lactide) (PDLLA) as the medium, the scaffolds can be exploited as a universal platform for loading different kinds of therapeutic agents. This study may provide insights into designing multifunctional local implantation for eradicating tumors after surgical interventions with mitigated side effects.
在临床骨肉瘤治疗中，术后肿瘤复发和化疗耐药提出了迫切需要开发局部植入物，以选择性杀伤残留的肿瘤细胞，并同时提供有效的支架填充肿瘤切除引起的骨缺损。在此，通过在磷酸三钙（TCP）支架表面依次涂覆氮化钛（TiN）微颗粒和阿霉素（DOX），开发了一种多功能平台，以实现骨肉瘤的光热治疗和化疗的协同作用。支架中 TiN 和 DOX 的含量可以通过将支架浸入含有不同浓度 TiN 和 DOX 的溶液中来灵活调节。通过精确的光热治疗和局部控制释放化疗，实现了优异的治疗效果。此外，整体块状支架在将支架植入骨肉瘤切除手术后的骨缺损中时，为骨组织提供机械支撑。重要的是，使用聚（D，L-乳酸）（PDLLA）作为介质，支架可以作为用于装载不同治疗剂的通用平台。本研究可能为设计用于减轻副作用的手术后消除肿瘤的多功能局部植入物提供思路。
