肺孢子菌定植于有呼吸窘迫综合征的早产儿。
Pneumocystis jirovecii Colonization in Preterm Newborns With Respiratory Distress Syndrome.
机构信息
Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland.
Department and Clinic of Neonatology, Wroclaw Medical University, Wroclaw, Poland.
出版信息
J Infect Dis. 2022 May 16;225(10):1807-1810. doi: 10.1093/infdis/jiab209.
Abstract
We describe the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns <32 weeks gestation. Molecular and microscopic methods were used for detection of P. jirovecii in patients' specimens. Pneumocystis DNA was detected in 8 nasopharyngeal aspirates (14%) of 56 newborns and in 7 oral washes (21%) of 34 mothers. Pneumocystis detection immediately after birth suggests the possibility of its transplacental transmission. Compared to noncolonized infants, more frequent occurrence of bronchopulmonary dysplasia was seen in colonized infants (P = .02), suggesting a potential clinical importance of this pathogen in abnormal lung development.
摘要
我们描述了在妊娠 32 周以下的极低出生体重儿母婴对中，耶氏肺孢子菌的流行情况。分子和显微镜方法用于检测患者标本中的耶氏肺孢子菌。在 56 名新生儿的 8 份鼻咽抽吸物（14%）和 34 名母亲的 7 份口腔冲洗液（21%）中检测到了耶氏肺孢子菌 DNA。出生后立即检测到耶氏肺孢子菌提示其可能经胎盘传播。与未定植的婴儿相比，定植的婴儿更常发生支气管肺发育不良（P=0.02），这表明该病原体在异常肺发育中可能具有潜在的临床重要性。
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