Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, P. R. China.
Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong 518055, P. R. China.
ACS Appl Mater Interfaces. 2021 Apr 28;13(16):18554-18562. doi: 10.1021/acsami.1c02045. Epub 2021 Apr 15.
Nanoscale metal-organic frameworks (MOFs) that are both fluorescent and hollow are attracting increasing interest in recent years, but ideal candidates prepared by reliable methods for biomedical applications are still very limited. Herein, we for the first time prepared tetrakis[4-(4-carboxyphenyl)phenyl]ethene (TCBPE)-based MOF nanotubes with hollow nanostructures, which could emit strong fluorescence. It was further discovered that the formation of this hollow hexagonal nanotube underwent a self-templated growth and a subsequent concaving process, which revealed that the synthesis of this MOF was kinetic rather than thermodynamic. This new MOF showed high biocompatibility, optical stability, sensitivity to pH response, and capability for exotic loading. This new MOF was further employed for efficient anti-cancer drug delivery in a self-indicating manner based on these attractive features. Therefore, this work could bring in valuable insights into the exploration of multifunctional MOFs in the field of biomedical applications by providing a new exemplar with high practical utility.
近年来，同时具有荧光性和中空结构的纳米级金属-有机骨架（MOF）引起了越来越多的关注，但可用于生物医学应用的理想候选物仍非常有限。在此，我们首次制备了具有中空纳米结构的四[4-（4-羧基苯基）苯基]乙烯（TCBPE）基 MOF 纳米管，其具有强荧光。进一步发现，这种中空六方纳米管的形成经历了自模板生长和随后的内凹过程，这表明该 MOF 的合成是动力学的而不是热力学的。这种新型 MOF 表现出高生物相容性、光学稳定性、对 pH 响应的敏感性以及对外来物质的负载能力。由于具有这些吸引人的特性，这种新型 MOF 进一步被用于基于自指示方式的高效抗癌药物输送。因此，这项工作通过提供一个具有高实际应用价值的新范例，为探索生物医学应用领域的多功能 MOF 提供了有价值的见解。
