Committee on Molecular Metabolism and Nutrition, The University of Chicago, 900 East 57th St, Chicago, IL 60637, USA.
Pritzker School of Medicine, The University of Chicago, 924 E 57th St, Chicago, IL 60637, USA.
Metabolism. 2021 Jul;120:154775. doi: 10.1016/j.metabol.2021.154775. Epub 2021 Apr 20.
Laminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. Through interactions with cell surface receptors, laminins stimulate intracellular signaling cascades which direct specific survival and differentiation outcomes. In metabolic tissues such as the pancreas, adipose, muscle, and liver, laminin isoforms are expressed in discrete temporal and spatial patterns suggesting that certain isoforms may support the development and function of particular metabolic cell types. This review focuses on the research to date detailing the expression of laminin isoforms, their potential function, as well as known pathways involved in laminin signaling in metabolic tissues. We will also discuss the current biomedical therapies involving laminins in these tissues in addition to prospective applications, with the goal being to encourage future investigation of laminins in the context of metabolic disease.
层粘连蛋白是细胞外基质蛋白，存在于基底膜中，除了促进细胞黏附和迁移外，还提供结构支持。通过与细胞表面受体相互作用，层粘连蛋白激活细胞内信号级联反应，从而指导特定的存活和分化结果。在代谢组织如胰腺、脂肪、肌肉和肝脏中，层粘连蛋白同工型以离散的时空模式表达，表明某些同工型可能支持特定代谢细胞类型的发育和功能。本综述重点介绍了迄今为止关于层粘连蛋白同工型表达、潜在功能以及代谢组织中层粘连蛋白信号通路的研究。我们还将讨论这些组织中涉及层粘连蛋白的当前生物医学疗法以及未来的应用，目标是鼓励未来在代谢疾病背景下研究层粘连蛋白。
