关于室性早搏和 PVC 引起的心肌病的临床和转化见解。
Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.
机构信息
Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America; Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States of America.
Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America; Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States of America.
出版信息
Prog Cardiovasc Dis. 2021 May-Jun;66:17-27. doi: 10.1016/j.pcad.2021.04.001. Epub 2021 Apr 20.
Abstract
The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.
摘要
医学领域对室性早搏（PVCs）及其引发的心肌病后果的认识主要来自观察性和基于大样本的研究。由于难以预测 PVC 性心肌病的发展，PVC 对心脏的急性和慢性影响及其引发心肌病的机制都来源于大型动物模型的临床前研究。最近，这些研究描述了心肌基质，这些基质可能会增加频发 PVC 和 PVC 性心肌病患者的发病率和死亡率。在本文中，我们对这些临床前和临床研究进行了全面的综述。
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