Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
J Inorg Biochem. 2021 Jul;220:111458. doi: 10.1016/j.jinorgbio.2021.111458. Epub 2021 Apr 8.
There has been growing interest in the application of gold nanorods (GNRs) to tumor therapy due to the unique properties they possess. In the past, GNRs were not used in clinical treatments as they lacked stability in vivo and were characterized by potential toxicity. Despite these issues, the significant potential for utilizing GNRs to conduct safe and effective treatments for tumors cannot be ignored. Therefore, it remains crucial to thoroughly investigate the mechanisms behind the toxicity of GNRs in order to provide the means of overcoming obstacles to its full application in the future. This review presents the toxic effects of GNRs, the factors affecting toxicity and the methods to improve biocompatibility, all of which are presently being studied. Finally, we conclude by briefly discussing the current research status of GNRs and provide additional perspective on the challenges involved along with the course of development for GNRs in the future.
由于具有独特的性质，金纳米棒（GNRs）在肿瘤治疗中的应用引起了越来越多的关注。过去，由于体内稳定性差且存在潜在毒性，GNRs 并未用于临床治疗。尽管存在这些问题，但利用 GNRs 进行安全有效的肿瘤治疗的巨大潜力不容忽视。因此，彻底研究 GNRs 毒性的机制仍然至关重要，以便为未来克服其全面应用的障碍提供手段。本综述介绍了 GNRs 的毒性作用、影响毒性的因素以及提高生物相容性的方法，目前正在对此进行研究。最后，我们简要讨论了 GNRs 的当前研究现状，并对未来 GNRs 的发展过程中所涉及的挑战提供了额外的观点。
