Mohanty Abhishek, Agnihotri Shalini, Mehta Anurag, Rawal Sudhir
Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
Pathol Res Pract. 2021 May;221:153417. doi: 10.1016/j.prp.2021.153417. Epub 2021 Mar 26.
The COVID-19 (coronavirus disease) pandemic caused by SARS-CoV-2 with its rapid expansion has led to extraordinary implications in our understanding of viral infections and their management globally. In this current scenario of unusual circumstances and public health emergency, the cancer care per se is facing unprecedented challenges. The peculiarity of the SARS-CoV-2 infections is still being uncovered as the pandemic spreads across the populations than showing signs of its curtailment. The review highlights the significance of idiosyncrasy of the SARS-Cov-2 infection especially putting forth the importance of immunosenescence, both in the COVID-19 specific immune response in the infected lungs of the elderly and in the cancer patients infected with SARS-CoV-2.The focus of the article is directed towards demystifying the unparalleled essence of a proprotein convertase, Furin in the biology of the SARS-Cov-2 infection and its role in facilitating viral transmission through expedited cellular entry into alveolar epithelial cells in COVID-19 infected cancer patients. The risk stratification of the cancer treatment and guidelines shaped up by national and international oncology societies in providing uncompromised patient care during the COVID-19 crisis have also been addressed. The global efforts towards vaccination in developing SARS CoV-2 immunity are also discussed in this article.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行迅速蔓延，给我们对全球病毒感染及其管理的理解带来了非凡影响。在当前这种特殊情况和突发公共卫生事件的背景下，癌症护理本身正面临前所未有的挑战。随着大流行在人群中蔓延而非呈现出缓解迹象，SARS-CoV-2感染的特殊性仍在不断被揭示。本综述强调了SARS-CoV-2感染特性的重要性，特别是阐述了免疫衰老的重要性，这在老年人感染COVID-19的肺部特异性免疫反应以及感染SARS-CoV-2的癌症患者中均有体现。文章重点在于揭开前体蛋白转化酶弗林蛋白酶（Furin）在SARS-CoV-2感染生物学中无与伦比的本质，以及它在COVID-19感染的癌症患者中通过加速病毒进入肺泡上皮细胞从而促进病毒传播方面所起的作用。文章还探讨了国家和国际肿瘤学会在COVID-19危机期间制定的癌症治疗风险分层和指南，以提供不打折扣的患者护理。本文还讨论了全球在研发SARS-CoV-2免疫力方面的疫苗接种努力。
