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Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.

作者信息

Madapusi Balaji Thodur, Varadarajan Saranya, Rao U S Vishal, Raj A Thirumal, Patil Shankaragouda, Arakeri Gururaj, Brennan Peter A

机构信息

Department of Dentistry, Bharathirajaa Hospital, and Research Institute, Chennai, India.

Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.

出版信息

Med Hypotheses. 2020 Nov;144:109936. doi: 10.1016/j.mehy.2020.109936. Epub 2020 Jun 1.

DOI:10.1016/j.mehy.2020.109936
PMID:32505073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7263251/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffb/7263251/2f927d28c86e/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffb/7263251/2f927d28c86e/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fffb/7263251/2f927d28c86e/gr1_lrg.jpg

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本文引用的文献

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Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.强效泛冠状病毒融合抑制剂抑制 SARS-CoV-2（前称 2019-nCoV）感染，该抑制剂针对病毒的刺突蛋白，具有很强的介导膜融合能力。
Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. Epub 2020 Mar 30.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
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Clin Oral Investig. 2023 Jun;27(Suppl 1):3-13. doi: 10.1007/s00784-023-04950-2. Epub 2023 Apr 20.
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Periodontal disease and COVID-19: Prognosis and potential pathways of association in their pathogenesis.牙周病与 COVID-19：发病机制中预后及潜在关联途径。
Can J Dent Hyg. 2023 Feb 1;57(1):44-51. eCollection 2023 Feb.
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Association between periodontitis and COVID-19 infection: a two-sample Mendelian randomization study.牙周炎与 COVID-19 感染的关联：一项双样本孟德尔随机化研究。
PeerJ. 2023 Jan 25;11:e14595. doi: 10.7717/peerj.14595. eCollection 2023.
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