Desiderio M A
General Motors Research Laboratories, Biomedical Science Department, Warren, Michigan 48090-9058.
J Trauma. 1988 Jun;28(6):765-71. doi: 10.1097/00005373-198806000-00007.
In our initial study in anesthetized dogs, single 7-minute intravenous alcohol doses caused a 67% mortality with cardiac impact at 65 mg% blood alcohol. In the next study, equally spaced oral doses over 40 minutes resulted in only a 17% mortality at an equivalent blood alcohol level and injury severity. Intravenous doses of a 50% ethanol/isotonic saline solution were given at equally spaced intervals over 40 minutes to generate peak blood alcohol levels and rates of rise equivalent to the oral study. Impacts with a velocity of 10 m/s and a contact compression of 5 cm were delivered to 85-90% of the right pericardial surface. The 25% mortality from alcohol and trauma was comparable to that observed in the oral study. These results attest to the importance of the rate of alcohol administration over the route on the outcome of cardiac injury.
在我们对麻醉犬的初步研究中，单次静脉注射7分钟的酒精剂量在血醇浓度达到65mg%时导致67%的死亡率，且对心脏产生影响。在接下来的研究中，在40分钟内给予等间隔口服剂量，在相同血醇水平和损伤严重程度下，死亡率仅为17%。在40分钟内等间隔静脉注射50%乙醇/等渗盐溶液，以产生与口服研究相当的血醇峰值水平和上升速率。以10米/秒的速度和5厘米的接触压缩对右心包表面的85 - 90%进行撞击。酒精和创伤导致的25%的死亡率与口服研究中观察到的相当。这些结果证明了酒精给药速率相对于给药途径对心脏损伤结果的重要性。
