Desiderio M A
J Trauma. 1986 May;26(5):467-73. doi: 10.1097/00005373-198605000-00011.
Acute changes in mechanical performance and electrical activity were followed after blunt cardiac trauma, ethanol infusion, and ethanol infusion and blunt cardiac trauma in 21 anesthetized dogs. Impact was delivered to most of the pericardium with an impact velocity of 10 m/sec and a contact compression of 5 cm. Impact alone caused transient arrhythmias and significant reductions in all hemodynamic parameters with ultimate recovery of rhythm and cardiac performance within 60 minutes after impact. Intravenous infusion of ethanol (average blood alcohol concentration, 65 +/- 1 mg %), resulted in no significant alterations in either mechanical performance or electrical activity but, when combined with trauma, caused a mortality rate of 67%. All animals died from excitation-contraction decoupling; a dissociation of electrical from mechanical activity such that an electrical event does not elicit a mechanical event strong enough to sustain life. It is concluded that even low blood alcohol concentrations can significantly reduce cardiac performance in the presence of otherwise nonfatal cardiac injury.
在21只麻醉犬中，观察了钝性心脏创伤、乙醇输注以及乙醇输注合并钝性心脏创伤后机械性能和电活动的急性变化。以10米/秒的撞击速度和5厘米的接触压缩对大部分心包进行撞击。单纯撞击会导致短暂性心律失常，所有血流动力学参数显著降低，撞击后60分钟内心律和心脏性能最终恢复。静脉输注乙醇（平均血醇浓度为65±1毫克%），机械性能或电活动均无显著改变，但与创伤合并时，死亡率为67%。所有动物均死于兴奋 - 收缩解偶联，即电活动与机械活动分离，使得电事件无法引发足以维持生命的机械事件。结论是，即使在血醇浓度较低的情况下，在原本非致命性心脏损伤存在时，也会显著降低心脏性能。
