Desiderio M A
J Trauma. 1987 Mar;27(3):267-77. doi: 10.1097/00005373-198703000-00007.
Acute changes in hemodynamic and electrophysiologic indices were measured following blunt cardiac trauma, oral ethanol, and a combination of both in dogs. Impacts with a velocity of 10 m/sec and a contact compression of 5 cm were delivered to most of the pericardium. Transient arrhythmias in impacted animals resulted in significant reductions in all hemodynamic responses at 15 minutes post-impact. Intragastric doses of 50% ethanol/distilled water yielded average blood alcohol concentrations of 60 +/- 10 mg%, 120 +/- 20 mg%, and 180 +/- 15 mg%. Alcohol effected significant reductions in dp/dt and cardiac index and elevations in total peripheral resistance during treatment. Alcohol and trauma resulted in per cent mortalities of 17, 50, and 71% for each such group primarily from electrical-mechanical dissociation. Surviving animals experienced significant declines in dp/dt, cardiac index, and mean aortic pressure at 15 minutes post-impact. Mean aortic pressure remained depressed while dp/dt, cardiac index, and total peripheral resistance returned to control values.
在犬类身上，测量了钝性心脏创伤、口服乙醇以及二者联合作用后血流动力学和电生理指标的急性变化。以10米/秒的速度和5厘米的接触压缩对大部分心包进行撞击。受撞击动物出现的短暂性心律失常导致撞击后15分钟时所有血流动力学反应显著降低。胃内给予50%乙醇/蒸馏水后，平均血液酒精浓度分别为60±10毫克%、120±20毫克%和180±15毫克%。在治疗期间，酒精使dp/dt和心脏指数显著降低，总外周阻力升高。酒精和创伤导致每组的死亡率分别为17%、50%和71%，主要死因为电机械分离。存活的动物在撞击后15分钟时dp/dt、心脏指数和平均主动脉压显著下降。平均主动脉压持续降低，而dp/dt、心脏指数和总外周阻力恢复到对照值。
