Comparison of the corticosteroid injection and hyaluronate in the treatment of chronic subacromial bursitis: A randomized controlled trial.

OBJECTIVE

To analyse the effectiveness of corticosteroid (CS) and hyaluronic acid (HA) subacromial - subdeltoid (SASD) injection compared with normal saline (NS) in patients with chronic subacromial bursitis (CSB).

DESIGN

A prospective three-arm double-blinded randomised controlled trial.

SETTING

Rehabilitation department of two teaching hospitals.

SUBJECTS

Patients with CSB ( = 186) divided into CS ( = 68), HA ( = 60), and NS ( = 58) groups.

INTERVENTIONS

Three SASD injections under ultrasound guidance: group A, 20 mg of triamcinolone; group B, 2.5 mL of HA; and group C, 2.5 mL of NS.

OUTCOME MEASURES

The primary outcome measures were the pain visual analogue scale (VAS) score at eight weeks. The secondary outcomes were scores on the Shoulder Pain and Disability Index (SPADI) and Shoulder Disability Questionnaire.

RESULTS

At eight weeks, the pain VAS scores during activity were 2.56 ± 2.29, 3.65 ± 2.50, and 4.71 ± 2.83 in the CS, HA, and NS groups, respectively (CS vs NS,  < 0.001; HA vs NS,  = 0.013; CS vs HA,  = 0.010). SPADI scores were 40.83 ± 21.75, 36.92 ± 22.78, and 33.35 ± 23.38 in the CS, HA, and NS groups, respectively (CS vs NS,  < 0.001; HA vs NS,  = 0.197; CS vs HA,  = 0.004).

CONCLUSION

Ultrasound-guided corticosteroid injection into the subacromial - subdeltoid bursa was proven to be effective and superior to hyaluronic acid and normal saline injection for treating CSB. Hyaluronic acid injection was only marginally more effective than normal saline injection. ClinicalTrials.gov: NCT02702206.