Julius Wolff Institute, Berlin Institute of Health at Charité-Universitaetsmedizin Berlin, 13353 Berlin, Germany.
BIH-Center for Regenerative Therapies, Berlin Institute of Health, Charité-Universitaetsmedizin Berlin, 13353 Berlin, Germany.
Cells. 2022 Feb 14;11(4):663. doi: 10.3390/cells11040663.
The subacromial bursa has long been demolded as friction-reducing tissue, which is often linked to shoulder pain and, therefore, partially removed during shoulder surgery. Currently, the discovery of the stem cell potential of resident bursa-derived cells shed a new light on the subacromial bursa. In the meanwhile, this neglected tissue is gaining more attention as to how it can augment the regenerative properties of adjacent tissues such as rotator cuff tendons. Specifically, the tight fibrovascular network, a high growth factor content, and the large progenitor potential of bursa-derived cells could complement the deficits that a nearby rotator cuff injury might experience due to the fact of its low endogenous regeneration potential. This review deals with the question of whether bursal inflammation is only a pain generator or could also be an initiator of healing. Furthermore, several experimental models highlight potential therapeutic targets to overcome bursal inflammation and, thus, pain. More evidence is needed to fully elucidate a direct interplay between subacromial bursa and rotator cuff tendons. Increasing attention to tendon repair will help to guide future research and answer open questions such that novel treatment strategies could harvest the subacromial bursa's potential to support healing of nearby rotator cuff injuries.
肩峰下滑囊长期以来一直被认为是一种减少摩擦的组织，它常与肩部疼痛有关，因此在肩部手术中常被部分切除。目前，人们发现驻留于滑囊的细胞具有干细胞潜能，这为肩峰下滑囊提供了新的认识。与此同时，这个被忽视的组织正受到越来越多的关注，因为它可以增强邻近组织（如肩袖肌腱）的再生特性。具体而言，滑囊衍生细胞的紧密纤维血管网络、高生长因子含量和大量祖细胞潜能，可以弥补因低内源性再生潜能而导致的邻近肩袖损伤的缺陷。本综述探讨了肩峰下滑囊炎是否仅仅是疼痛的产生者，还是可以作为愈合的启动者。此外，几个实验模型强调了克服滑囊炎症和疼痛的潜在治疗靶点。需要更多的证据来充分阐明肩峰下滑囊和肩袖肌腱之间的直接相互作用。对肌腱修复的日益关注将有助于指导未来的研究，并回答悬而未决的问题，从而使新的治疗策略能够利用肩峰下滑囊的潜力来支持邻近肩袖损伤的愈合。
