用于在新冠疫情期间测试呼吸机原型的绵羊模型描述
Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic.
作者信息
Viscasillas J, Alonso-Iñigo J M, Gutierrez-Bautista A, Casañ Pallardó M, Redondo J I
机构信息
Departamento de Medicina y Cirugía Animal, Hospital Clínico Veterinario. Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Servicio de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital Universitari i Politécnic La Fe de Valencia, España.
出版信息
Rev Esp Anestesiol Reanim (Engl Ed). 2020 Oct 23;68(10):592-6. doi: 10.1016/j.redar.2020.10.002.
The COVID-19 pandemic has revealed a ventilator deficit in the global health system for this scenario. For this reason, several national and international projects have been developed to get done prototypes of ventilators which could be easy and fast to manufacture. One of the requirements of the AEMPS for conducting clinical studies with new prototypes is through the validation of these new prototypes in an animal model. Therefore, it is important to achieve an animal model which allows us to easily reproduce different clinical scenarios. In this article, we describe the use of a sheep as a research model to assess a prototype ventilator. The animal was anesthetized for 10hours in which the prototype was tested in up to 6different scenarios. This model is effective and easy to reproduce, making it an excellent choice for this kind of research.
2019年冠状病毒病疫情暴露出全球卫生系统在应对这种情况时存在呼吸机短缺的问题。因此，已经开展了几个国家和国际项目来制造易于快速生产的呼吸机原型。西班牙药品和医疗器械管理局（AEMPS）对新原型进行临床研究的要求之一是在动物模型中验证这些新原型。因此，建立一个能够让我们轻松再现不同临床场景的动物模型非常重要。在本文中，我们描述了使用绵羊作为研究模型来评估一种呼吸机原型。该动物被麻醉10小时，在此期间该原型在多达6种不同场景下进行了测试。这个模型有效且易于复制，使其成为这类研究的绝佳选择。
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